[HTML][HTML] The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity
The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative
genomic approaches, an additional accessory protein, ORF3c, has been predicted to be …
genomic approaches, an additional accessory protein, ORF3c, has been predicted to be …
SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux
A Mozzi, M Oldani, ME Forcella, C Vantaggiato… - Iscience, 2023 - cell.com
Coronaviruses encode a variable number of accessory proteins that are involved in host-
virus interaction, suppression of immune responses, or immune evasion. SARS-CoV-2 …
virus interaction, suppression of immune responses, or immune evasion. SARS-CoV-2 …
ORF9c and ORF10 as accessory proteins of SARS-CoV-2 in immune evasion
M Zandi - Nature Reviews Immunology, 2022 - nature.com
In a recent Perspective article in Nature Reviews Immunology (Wong, LY. R. & Perlman, S.
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related …
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related …
[HTML][HTML] Sex differences in antiviral immunity in SARS‐CoV‐2 infection: mitochondria and mitomiR come into view
E Iessi, C Cittadini, S Anticoli, K Fecchi… - Acta Physiologica …, 2021 - ncbi.nlm.nih.gov
Mitochondria are multifaceted organelles representing the 'powerhouse of cells' for their
function as bioenergetics and biosynthetic hubs. In addition, they play an essential role in …
function as bioenergetics and biosynthetic hubs. In addition, they play an essential role in …
Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis
Because of the ongoing pandemic around the world, the mechanisms underlying the SARS-
CoV-2-induced COVID-19 are subject to intense investigation. Based on available data for …
CoV-2-induced COVID-19 are subject to intense investigation. Based on available data for …
Metabolic and mitochondria alterations induced by SARS‐CoV‐2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10
BD López‐Ayllón, S Marin… - Journal of Medical …, 2024 - Wiley Online Library
Antiviral signaling, immune response and cell metabolism are dysregulated by SARS‐CoV‐
2, the causative agent of COVID‐19. Here, we show that SARS‐CoV‐2 accessory proteins …
2, the causative agent of COVID‐19. Here, we show that SARS‐CoV‐2 accessory proteins …
Mitochondria: in the cross fire of SARS-CoV-2 and immunity
J Burtscher, G Cappellano, A Omori, T Koshiba… - IScience, 2020 - cell.com
The pathophysiology, immune reaction, and differential vulnerability of different population
groups and viral host immune system evasion strategies of severe acute respiratory …
groups and viral host immune system evasion strategies of severe acute respiratory …
SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy
X Li, P Hou, W Ma, X Wang, H Wang, Z Yu… - Cellular & molecular …, 2022 - nature.com
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and …
The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis
S Lenhard, S Gerlich, A Khan, S Rödl… - Journal of Cell …, 2023 - rupress.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) expresses high
amounts of the protein Orf9b to target the mitochondrial outer membrane protein Tom70 …
amounts of the protein Orf9b to target the mitochondrial outer membrane protein Tom70 …
Binding of SARS-CoV-2 protein ORF9b to mitochondrial translocase TOM70 prevents its interaction with chaperone HSP90
The emergence of the COVID-19 pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), remains a great threat to global health. ORF9b, an important …
coronavirus 2 (SARS-CoV-2), remains a great threat to global health. ORF9b, an important …
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