Background: Nattokinase is a potent fibrinolytic protease, which is used as a drug for
treatment or a supplement for preventing thrombosis besides various industrial applications …

Nattokinase, a serine protease, was discovered in Bacillus subtilis during the fermentation of
a soybean byproduct. Nattokinase is essential for the lysis of blood clots and the treatment of …

Nattokinase producing bacterium, B. subtilis YF38, was isolated from douchi, using the fibrin
plate method. The gene encoding this enzyme was cloned by polymerase chain reaction …

Nattokinase (NK) is a fibrinolytic enzyme with the potential for fighting cardiovascular
diseases (CVD) thanks to its antithrombotic, antihypertensive, anticoagulant, anti …

This study was conducted with the aim to isolate, characterize and optimize of Bacillus
subtilis that produce nattokinase with highest activity under optimal culture conditions. The …

Heterologous expression of nattokinase, a potent fibrinolytic enzyme, has been successfully
carried out in various microorganisms. However, the successful expression of this enzyme …

The results presented in this study were based on purifying and characterizing the
nattokinase produced from local isolate of Bacillus sp. B24. Nattokinase was purified by two …

Abstract Nattokinase (EC 3.4. 21.62) is a profibrinolytic serine protease with a potent fibrin-
degrading activity, and it has been produced by many host strains. Compared to other …

Nattokinase is an important fibrinolytic enzyme with therapeutic applications for
cardiovascular diseases. The full-length and mature nattokinase genes were cloned from …

Nattokinase, traditionally produced by the fermentation of Bacillus natto, has a high-
efficiency and safe thrombolytic effect. However, low activity limits its industrial application as …