Current and Ongoing Developments in Targeting Clostridioides difficile Infection and Recurrence

WY Cun, PA Keller, SG Pyne - Microorganisms, 2024 - mdpi.com
Clostridioides difficile is a Gram-positive, spore-forming anaerobic bacterial pathogen that
causes severe gastrointestinal infection in humans. This review provides background …

Clostridioides difficile therapeutics: guidelines and beyond

R Orenstein, RL Patron - Therapeutic Advances in Infectious …, 2019 - journals.sagepub.com
Clostridioides difficile infection (CDI) has become an increasingly common infection both
within and outside of the hospital setting. The management of this infection has been …

[HTML][HTML] Clostridioides difficile infection: microbe-microbe interactions and live biotherapeutics

R Wang - Frontiers in Microbiology, 2023 - frontiersin.org
Clostridioides difficile is a gram-positive, spore-forming, obligate anaerobe that infects the
colon. C. difficile is estimated to cause nearly half a million cases in the United States …

Anti-virulence strategies for Clostridioides difficile infection: advances and roadblocks

D Stewart, F Anwar, G Vedantam - Gut Microbes, 2020 - Taylor & Francis
Clostridioides difficile infection (CDI) is a common healthcare-and antibiotic-associated
diarrheal disease. If mis-diagnosed, or incompletely treated, CDI can have serious, indeed …

Clostridioides difficile: current overview and future perspectives

J Giles, A Roberts - Advances in Protein Chemistry and Structural Biology, 2022 - Elsevier
The most common world-wide cause of antibiotic-associated infectious diarrhea and colitis
is the toxin producing bacterium, Clostridioides difficile (C. difficile). Here we review the …

Emerging alternatives against Clostridioides difficile infection

A Romero-Rodríguez, CM de la Peña… - Anaerobe, 2022 - Elsevier
Clostridioides difficile infection (CDI) is a significant worry within healthcare institutions and
the community. It is one of the leading agents causing severe diarrhea worldwide. Effective …

Follow your Gut: Microbiome-Based Approaches in the Developmental Pipeline for the Prevention and Adjunctive Treatment of Clostridioides difficile Infection (CDI)

AJ Gonzales-Luna, TJ Carlson - Current Infectious Disease Reports, 2020 - Springer
Abstract Purpose of Review Antibiotic use is the most important modifiable risk factor for the
development of Clostridioides difficile infection (CDI). In addition, up to a quarter of patients …

Novel therapies and preventative strategies for primary and recurrent Clostridium difficile infections

MG Dieterle, K Rao, VB Young - … of the New York Academy of …, 2019 - Wiley Online Library
Clostridium difficile is the leading infectious cause of antibiotic‐associated diarrhea and
colitis. C. difficile infection (CDI) places a heavy burden on the healthcare system, with …

[HTML][HTML] Breakthroughs in the treatment and prevention of Clostridium difficile infection

LK Kociolek, DN Gerding - Nature reviews Gastroenterology & …, 2016 - nature.com
This Review summarizes the latest advances in the treatment and prevention of Clostridium
difficile infection (CDI), which is now the most common health-care-associated infection in …

Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

S Di Bella, G Sanson, J Monticelli… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …