Poly (adenosine 5′-diphosphoribose) synthetase (PARS) has been described as an
important candidate for mediation of neurotoxicity by nitric oxide. In the current study, we …

In the present study, the effect of poly (ADP-ribose) polymerase (PARP) inhibition on rat
cortical energy state was investigated at 24 h after global cerebral ischemia induced by …

Aim To explore the role of poly (ADP-ribose) polymerase (PARP) in focal cerebral ischemia
with reperfusion injury. Methods Male Wistar rats underwent 3.5-h of temporary middle …

Poly (ADP-ribose) polymerase (PARP) can initiate an energy-consuming and inefficient
repair cycle following cerebral ischemia/reperfusion by transferring ADP ribose units to …

Poly (ADP-ribose) polymerase (PARP) is thought to play a physiological role in maintaining
genomic integrity and in the repair of DNA strand breaks. However, the activation of PARP …

Poly (ADP‐ribose) synthase (PARS), an abundant nuclear protein, has been described as
an important candidate for mediation of neurotoxicity by nitric oxide. However, in cerebral …

In the present study, neuroprotective effect of 4-amino-1, 8-napthalimide (4-ANI), a poly
(ADP-ribose) polymerase (PARP) inhibitor was investigated in middle cerebral artery …

The activation of poly (ADP-ribose) polymerase (PARP) in the reperfused brain after
ischemia has been assumed but never has been directly presented. Our studies indicate a …

Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) in response to DNA damage is
considered to play a crucial role in the development of post-ischemic neuronal injury, such …

The nuclear enzyme poly (ADP-ribose) polymerase (PARP) is activated by oxidative stress
and plays a significant role in postischemic brain injury. We assessed the contribution of …