The controversial abscopal effect
JM Kaminski, E Shinohara, JB Summers… - Cancer treatment …, 2005 - Elsevier
The abscopal effect is potentially important for tumor control and is mediated through
cytokines and/or the immune system, mainly cell-mediated immunity. It results from loss of …
cytokines and/or the immune system, mainly cell-mediated immunity. It results from loss of …
[HTML][HTML] Abscopal effect, from myth to reality: from radiation oncologists' perspective
The abscopal effect is mediated by a systemic anti-tumor immune response and reflects the
regression of non-irradiated metastatic lesions at a distance from the primary site of …
regression of non-irradiated metastatic lesions at a distance from the primary site of …
Abscopal effects of radiation therapy: a clinical review for the radiobiologist
An “abscopal” effect occurs when localized irradiation perturbs the organism as a whole,
with consequences that can be either beneficial or detrimental. Mechanistic explanations of …
with consequences that can be either beneficial or detrimental. Mechanistic explanations of …
Systematic review of case reports on the abscopal effect
Radiation therapy is a highly effective local treatment for cancer. However, sporadic events
of tumor regression in unirradiated fields, known as abscopal effect, have been observed for …
of tumor regression in unirradiated fields, known as abscopal effect, have been observed for …
The abscopal effect 67 years later: from a side story to center stage
S Demaria, SC Formenti - The British Journal of Radiology, 2020 - academic.oup.com
For over a century, ionising radiation has been used to treat cancer based on its cytotoxic
effects on tumour cells. Technical progress has enabled more precise targeting of the …
effects on tumour cells. Technical progress has enabled more precise targeting of the …
[HTML][HTML] Radiation therapy and the abscopal effect: a concept comes of age
J Ng, T Dai - Annals of translational medicine, 2016 - ncbi.nlm.nih.gov
The concept of utilizing localized radiation therapy to elicit out-of-target tumor responses—
the abscopal effect—was proposed over 50 years ago (1, 2). Over the past decades, the …
the abscopal effect—was proposed over 50 years ago (1, 2). Over the past decades, the …
Abscopal effect in lung cancer: three case reports and a concise review
E Garelli, A Rittmeyer, PM Putora, M Glatzer… - …, 2019 - Taylor & Francis
The abscopal effect describes the ability of locally administered radiotherapy to induce
systemic antitumor effects. Over the past 40 years, reports on the abscopal effect following …
systemic antitumor effects. Over the past 40 years, reports on the abscopal effect following …
[HTML][HTML] The abscopal effect of radiation therapy: what is it and how can we use it in breast cancer?
ZI Hu, HL McArthur, AY Ho - Current breast cancer reports, 2017 - Springer
The abscopal effect refers to the ability of localized radiation to trigger systemic antitumor
effects. Over the past 50 years, reports on the abscopal effect arising from conventional …
effects. Over the past 50 years, reports on the abscopal effect arising from conventional …
The immune mechanisms of abscopal effect in radiation therapy
Radiation therapy (RT) is a cornerstone in oncologic management and is employed in
various curative and palliative scenarios for local-regional control. RT is thought to locally …
various curative and palliative scenarios for local-regional control. RT is thought to locally …
The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant
Background Recently, immunologic responses to localized irradiation are proposed as
mediator of systemic effects after localized radiotherapy (called the abscopal effect). Here …
mediator of systemic effects after localized radiotherapy (called the abscopal effect). Here …