Objective The lack of accurate biomarkers to predict knee osteoarthritis (OA) progression is
a key unmet need in OA clinical research. The objective of this study was to develop …

Knee osteoarthritis (OA) is a leading cause of chronic disability worldwide, but no diagnostic
or prognostic biomarkers are available. Increasing evidence supports epigenetic …

Identifying predictive biomarkers at early stages of inflammatory arthritis is crucial for starting
appropriate therapies to avoid poor outcomes. Monocytes (MOs) and macrophages, largely …

Our study aimed to identify differentially methylated regions (ie, genomic region where
multiple adjacent CpG sites show differential methylation) and their enriched genomic …

Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …

Objective To perform a genome‐wide DNA methylation study to identify differential DNA
methylation patterns in subchondral bone underlying eroded and intact cartilage from …

Objective The term “undifferentiated arthritis (UA)” is used to refer to all cases of arthritis that
do not fit a specific diagnosis. A significant percentage of UA patients progress to …

In this study, we sought to characterize synovial tissue obtained from individuals with
arthralgia and disease-specific auto-antibodies and patients with established rheumatoid …

Objective The aim of this study was to characterize the genome‐wide DNA methylation
profile of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis …

Background Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease
of the joints that has been associated with variation in the peripheral blood methylome. In …