Cellular and molecular mechanisms of arrhythmia by oxidative stress

AA Sovari - Cardiology Research and Practice, 2016 - Wiley Online Library
Current therapies for arrhythmia using ion channel blockade, catheter ablation, or an
implantable cardioverter defibrillator have limitations, and it is important to search for new …

Metabolic stress, reactive oxygen species, and arrhythmia

EM Jeong, M Liu, M Sturdy, G Gao, ST Varghese… - Journal of molecular and …, 2012 - Elsevier
Cardiac arrhythmias can cause sudden cardiac death (SCD) and add to the current heart
failure (HF) health crisis. Nevertheless, the pathological processes underlying arrhythmias …

Redox control of cardiac excitability

NT Aggarwal, JC Makielski - Antioxidants & redox signaling, 2013 - liebertpub.com
Reactive oxygen species (ROS) have been associated with various human diseases, and
considerable attention has been paid to investigate their physiological effects. Various ROS …

Reactive oxygen species, endoplasmic reticulum stress and mitochondrial dysfunction: the link with cardiac arrhythmogenesis

G Tse, BP Yan, YWF Chan, XY Tian… - Frontiers in Physiology, 2016 - frontiersin.org
Background: Cardiac arrhythmias represent a significant problem globally, leading to
cerebrovascular accidents, myocardial infarction, and sudden cardiac death. There is …

Role of oxidative stress in the genesis of ventricular arrhythmias

A Adameova, AK Shah, NS Dhalla - International Journal of Molecular …, 2020 - mdpi.com
Ventricular arrhythmias, mainly lethal arrhythmias, such as ventricular tachycardia and
fibrillation, may lead to sudden cardiac death. These are triggered as a result of cardiac …

[HTML][HTML] Defining the role of oxidative stress in atrial fibrillation and diabetes

MT Ziolo, PJ Mohler - Journal of cardiovascular electrophysiology, 2015 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most common form of arrhythmia, currently estimated to affect
over 33 million individuals worldwide. 1 The incidence of AF continues to grow, and …

Oxidative stress and atrial fibrillation: finding a missing piece to the puzzle

KC Yang, SC Dudley Jr - Circulation, 2013 - Am Heart Assoc
did not show an increase in Ca2+ sparks or DADs, suggesting the requirement of ox-CaMKII
in AngII-induced SR Ca2+ leak and DADs. Finally, they demonstrated that the proarrhythmic …

Mitochondrial oxidative stress promotes atrial fibrillation

W Xie, G Santulli, SR Reiken, Q Yuan, BW Osborne… - Scientific reports, 2015 - nature.com
Oxidative stress has been suggested to play a role in the pathogenesis of atrial fibrillation
(AF). Indeed, the prevalence of AF increases with age as does oxidative stress. However …

Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress

L André, F Gouzi, J Thireau, G Meyer… - Basic Research in …, 2011 - Springer
Arrhythmias following cardiac stress are a key predictor of death in healthy population.
Carbon monoxide (CO) is a ubiquitous pollutant promoting oxidative stress and associated …

The role of oxidative stress in cardiac disease: from physiological response to injury factor

R D'Oria, R Schipani, A Leonardini… - Oxidative medicine …, 2020 - Wiley Online Library
Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen,
controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart …