Background Epidemiologic and laboratory investigations suggest that aspirin and other
nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive effects against colon …

Colorectal cancer (CRC) accounts for nearly 12% of newly diagnosed cancers in the United
States and is the second leading cause of cancer deaths (1, 2). Multidisciplinary research in …

Background There are limited population-based studies focusing on the chemopreventive
effects of selective cyclooxygenase-2 (COX-2) inhibitors against colorectal cancer. The …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …

Colorectal cancer is a major cause of morbidity and mortality accounting for an estimated
550,000 deaths annually worldwide. Colonic neoplasia develops in a stepwise fashion …

During recent years, multidisciplinary studies in epidemiology and molecular biology, as
well as preclinical studies, have contributed much to our understanding of the etiology of …

The seminal epidemiological observation that nonsteroidal anti-inflammatory drugs
(NSAIDs) prevent colon and possibly other cancers has spurred novel approaches to cancer …

The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …

The compelling evidence that chronic use of aspirin or certain nonsteroidal antiinflammatory
drugs (NSAIDs) can substantially lower the risk of colon cancer has important implications …

Epidemiological and experimental studies indicate an inverse relationship between the risk
of colon cancer development and intake of aspirin and other nonsteroidal antiinflammatory …