Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely
interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory …

Cellular senescence is a process that results from a variety of stresses, leading to a state of
irreversible growth arrest. Senescent cells accumulate during aging and have been …

Cellular senescence and mitochondrial dysfunction have both been defined as classical
hallmarks of the ageing process. Here, we review the intricate relationship between the two …

Cell senescence is increasingly recognized as a major contributor to the loss of health and
fitness associated with aging. Senescent cells accumulate dysfunctional mitochondria; …

Senescence is a multi‐functional cell fate, characterized by an irreversible cell‐cycle arrest
and a pro‐inflammatory phenotype, commonly known as the senescence‐associated …

Cellular senescence refers to a stress response aiming to preserve cellular and, therefore,
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …

A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

Mitochondria are intimately connected to cell fate and function. Here, we review how these
intracellular organelles participate in the induction and maintenance of the senescent state …

Cellular senescence entails an irreversible cell-cycle arrest characterised by drastic
cytomorphological and metabolic changes. In recent years, the implications of cellular …

Aging is a natural phenomenon characterized by progressive decline in tissue and organ
function leading to increased risk of disease and mortality. Among diverse factors that …