Abstract Aims The Hygia Chronotherapy Trial, conducted within the clinical primary care
setting, was designed to test whether bedtime in comparison to usual upon awakening …

Diagnosis of hypertension—elevated blood pressure (BP) associated with increased
cardiovascular disease (CVD) risk—and its management for decades have been based …

Clinical studies have documented morning-evening, administration-time differences of
several different classes of hypertension medications in blood pressure (BP)-lowering …

Correlation between blood pressure (BP) and target organ damage, vascular risk and long-
term patient prognosis is greater for measurements derived from around-the-clock …

Correlation between blood pressure (BP) and target organ damage, vascular risk, and long-
term patient prognosis is stronger for measurements derived from around-the-clock …

Because they were intrigued by the results, many colleagues and journalists have made us
aware of the paper “Bedtime hypertension treatment improves cardiovascular risk reduction …

Objective: To review evidence for dosing antihypertensives at bedtime and possible
cardiovascular risk reduction. Data Sources: A PubMed, EMBASE, and Cochrane Controlled …

Introduction Sleep-time blood pressure correlates more strongly with adverse cardiovascular
events than does daytime blood pressure. The BedMed trial evaluates whether bedtime …

Appreciation of chronotherapy in hypertension continues to lag, despite clear
demonstrations by many studies of (i) clinically relevant dosing-time differences of the …

In resistant hypertension, ingesting one or more blood pressure (BP)-lowering medications
at bedtime is associated with significant reduction of sleep-time BP, a sensitive prognostic …