Abstract pH-sensitive liposomes are interesting carriers for drug-delivery, undertaking rapid
bilayer destabilization in response to pH changes, allied to tumor accumulation, a desirable …

The killing efficacy of doxorubicin from liposome-based delivery carriers has been shown to
correlate strongly with its intracellular trafficking and, in particular, its fast and extensive …

We have reported that targeted, pH-sensitive sterically stabilized liposomes are able to
increase the cytotoxicity of DXR in vitro against B lymphoma cells, but the rate of release of …

Targeted liposomal drug formulations may enter cells by receptor-mediated endocytosis and
then traffick by membrane flow into acidic intracellular compartments. In order to understand …

Doxorubicin (DOX) is widely used in cancer treatment, however, the use of this drug is often
limited due to its cardiotoxic side effects. In order to avoid these adverse effects, the …

This study investigates the impact of the chemical nature of lipids and additive on the
formulation and properties of pH sensitive liposomes. The objective is to understand the …

Liposomes have been used widely to improve the therapeutic activity of pharmaceutical
agents. The traditional approach for such applications has been to formulate the …

Doxorubicin (DOX) is a potent anti-cancer agent that has garnered great interest in research
due to its high efficacy despite dose-limiting toxicities. Several strategies have been …

Drug release from liposomes in the endosome-lysosomal organelles into cytoplasm is
critical to cytotoxicity and anticancer effects. Chloroquine is a lysosomotropic agent that has …

Doxil, a liposomal formulation of the chemotherapeutic drug doxorubicin, is FDA-approved
for multiple indications. Doxil liposomes are designed to retain doxorubicin in circulation …