Studies have demonstrated that reactive oxygen species (ROS) are closely related to
inflammatory disorders. Nicotinamide adenine dinucleotide phosphate oxidase (NOX) …

Glucose in chronic excess causes toxic effects on structure and function of organs, including
the pancreatic islet. Multiple biochemical pathways and mechanisms of action for glucose …

Redox stress related loss of beta cell function is a feature of diabetes. Exposure of beta cells
and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell …

Pancreatic β-cell function continuously deteriorates in type 2 diabetes despite optimal
treatment regimens, which has been attributed to hyperglycemia itself via formation of …

Reactive oxygen species (ROS) and nitric oxide (NO) are proposed mediators of cytokine-
induced β-cell destruction in type 1 diabetes. We produced transgenic mice with increased β …

Since the landmark discovery of α, β-unsaturated 4-hydroxyalkenals by Esterbauer and
colleagues most studies have addressed the consequences of the tendency of these lipid …

The reduction of pancreatic β-cell mass is an important factor in the development of type 1
and type 2 diabetes. Understanding the mechanisms that regulate the maintenance of …

Elevated plasma concentration of the pro-atherogenic oxidized low density lipoprotein
cholesterol (LDL) triggers adverse effects in pancreatic beta-cells and is associated with …

It is now widely accepted that reactive oxygen species (ROS) contribute to cell and tissue
dysfunction and damage in diabetes. The source of ROS in the insulin secreting pancreatic …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) direct the activation of
distinct signaling pathways that determine cell fate. In this study, the pathways activated and …