Pancreatic β-cell failure is the common characteristic of type 1 and type 2 diabetes. Type 1
diabetes is induced by pancreatic β-cell destruction, which is mediated by an autoimmune …

Abstract Autoimmune Type 1 A Diabetes (T1D) is characterized by dependence on
exogenous insulin consequential to the autoimmune attack and destruction of insulin …

Pancreatic β-cells are susceptible to oxidative stress, which is related closely to the islet
dysfunction. In the present study, using the pancreatic cell lines HIT-T15 and RINm5F as …

High glucose-induced oxidative stress and increased NADPH oxidase-2 (NOX2) activity
may contribute to the progressive decline of the functional β-cell mass in type 2 diabetes. To …

Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …

Pancreatic β‐cells are vulnerable to oxidative stress due to their low content of redox buffers,
such as glutathione, but possess a rich content of thioredoxin, peroxiredoxin, and other …

Type 2 diabetes mellitus, the most prevalent and serious metabolic disease worldwide, is
believed to result from the interaction between genetical and lifestyle factors. In genetically …

Oxidative stress is caused by the overproduction of Reactive Oxygen Species (ROS) and
diminished cellular antioxidant defenses. Under physiological conditions, ROS are involved …

Predictions of diabetes prevalence over the next decades warrant the aggressive discovery
of new approaches to stop or reverse loss of functional beta cell mass. Beta cells are …

Insulin-secreting pancreatic β-cells play a critical role in blood glucose homeostasis and the
development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data …