Involvement of oxidative stress in the pathogenesis of diabetes
H Kaneto, N Katakami, D Kawamori… - Antioxidants & redox …, 2007 - liebertpub.com
Pancreatic β-cell failure is the common characteristic of type 1 and type 2 diabetes. Type 1
diabetes is induced by pancreatic β-cell destruction, which is mediated by an autoimmune …
diabetes is induced by pancreatic β-cell destruction, which is mediated by an autoimmune …
Oxidative stress and beta cell dysfunction
YL Lightfoot, J Chen, CE Mathews - Autoimmunity: Methods and Protocols, 2012 - Springer
Abstract Autoimmune Type 1 A Diabetes (T1D) is characterized by dependence on
exogenous insulin consequential to the autoimmune attack and destruction of insulin …
exogenous insulin consequential to the autoimmune attack and destruction of insulin …
Regulation of the susceptibility to oxidative stress by cysteine availability in pancreatic β-cells
S Numazawa, H Sakaguchi, R Aoki… - … of Physiology-Cell …, 2008 - journals.physiology.org
Pancreatic β-cells are susceptible to oxidative stress, which is related closely to the islet
dysfunction. In the present study, using the pancreatic cell lines HIT-T15 and RINm5F as …
dysfunction. In the present study, using the pancreatic cell lines HIT-T15 and RINm5F as …
NADPH oxidase-2 does not contribute to β-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice
AH de Souza, LRB Santos, LP Roma… - Molecular and cellular …, 2017 - Elsevier
High glucose-induced oxidative stress and increased NADPH oxidase-2 (NOX2) activity
may contribute to the progressive decline of the functional β-cell mass in type 2 diabetes. To …
may contribute to the progressive decline of the functional β-cell mass in type 2 diabetes. To …
[HTML][HTML] Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress
PV Dludla, SE Mabhida, K Ziqubu… - World journal of …, 2023 - ncbi.nlm.nih.gov
Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …
Potential of Mitochondria‐Targeted Antioxidants to Prevent Oxidative Stress in Pancreatic β‐cells
L Plecitá-Hlavatá, H Engstová, J Ježek… - Oxidative medicine …, 2019 - Wiley Online Library
Pancreatic β‐cells are vulnerable to oxidative stress due to their low content of redox buffers,
such as glutathione, but possess a rich content of thioredoxin, peroxiredoxin, and other …
such as glutathione, but possess a rich content of thioredoxin, peroxiredoxin, and other …
Oxidative stress and its effects on insulin resistance and pancreatic beta-cells dysfunction: relationship with type 2 diabetes mellitus complications
JP Lopes, SM Oliveira - Acta medica portuguesa, 2008 - europepmc.org
Type 2 diabetes mellitus, the most prevalent and serious metabolic disease worldwide, is
believed to result from the interaction between genetical and lifestyle factors. In genetically …
believed to result from the interaction between genetical and lifestyle factors. In genetically …
[PDF][PDF] The interplay of oxidative stress and inflammation: mechanistic insights and therapeutic potential of antioxidants
AM Mahmoud, FL Wilkinson, MA Sandhu… - … Medicine and Cellular …, 2021 - researchgate.net
Oxidative stress is caused by the overproduction of Reactive Oxygen Species (ROS) and
diminished cellular antioxidant defenses. Under physiological conditions, ROS are involved …
diminished cellular antioxidant defenses. Under physiological conditions, ROS are involved …
NOX, NOX who is there? The contribution of NADPH oxidase one to beta cell dysfunction
DA Taylor-Fishwick - Frontiers in endocrinology, 2013 - frontiersin.org
Predictions of diabetes prevalence over the next decades warrant the aggressive discovery
of new approaches to stop or reverse loss of functional beta cell mass. Beta cells are …
of new approaches to stop or reverse loss of functional beta cell mass. Beta cells are …
Nutrient metabolism, subcellular redox state, and oxidative stress in pancreatic islets and β-cells
Insulin-secreting pancreatic β-cells play a critical role in blood glucose homeostasis and the
development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data …
development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data …