A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity,
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …

Oxidative stress is produced under diabetic conditions and is likely involved in progression
of pancreatic beta-cell dysfunction found in diabetes. Possibly due to low levels of …

Background Oxidative stress (OS), through excessive and/or chronic reactive oxygen
species (ROS), is a mediator of diabetes-related damages in various tissues including …

Humans are constantly exposed to many environmental pollutants, some of which have
been largely acknowledged as key factors in the development of metabolic disorders such …

Cells are sensitive to a variety of signals in their environment, which they respond to and
integrate. Signal transduction at the cellular level refers to the movement of signals from …

Redox reactions are imperative to preserving cellular metabolism yet must be strictly
regulated. Imbalances between reactive oxygen species (ROS) and antioxidants can initiate …

Insulin resistance and β cell dysfunction contribute to the pathogenesis of type 2 diabetes.
Unlike insulin resistance, β cell dysfunction remains difficult to predict and monitor, because …

Type 2 diabetes (T2D) is a complex metabolic disorder characterized by hyperglycemia in
the context of insulin resistance, which precedes insulin deficiency as a result of β-cell …

The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

Nucleotide-binding oligomerization domain protein-2 (NOD2) activation in skeletal muscle
cells has been associated with insulin resistance, but the underlying mechanisms are not yet …