Lipotoxicity and β-cell failure in type 2 diabetes: Oxidative stress linked to NADPH oxidase and ER stress
A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity,
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …
Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes.
H Kaneto, D Kawamori, Y Nakatani… - Drug news & …, 2004 - europepmc.org
Oxidative stress is produced under diabetic conditions and is likely involved in progression
of pancreatic beta-cell dysfunction found in diabetes. Possibly due to low levels of …
of pancreatic beta-cell dysfunction found in diabetes. Possibly due to low levels of …
Diabetic β-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses
G Lacraz, F Figeac, J Movassat, N Kassis, J Coulaud… - PLoS …, 2009 - journals.plos.org
Background Oxidative stress (OS), through excessive and/or chronic reactive oxygen
species (ROS), is a mediator of diabetes-related damages in various tissues including …
species (ROS), is a mediator of diabetes-related damages in various tissues including …
Exploring the effects of metabolism-disrupting chemicals on pancreatic α-cell viability, gene expression and function: a screening testing approach
R Al-Abdulla, H Ferrero, T Boronat-Belda… - International Journal of …, 2023 - mdpi.com
Humans are constantly exposed to many environmental pollutants, some of which have
been largely acknowledged as key factors in the development of metabolic disorders such …
been largely acknowledged as key factors in the development of metabolic disorders such …
[PDF][PDF] A “cross-talk” between oxidative stress and redox cell signaling
D Pavlović, V Đorđević, G Kocić - Facta Unıv Series: Med Biol, 2002 - facta.junis.ni.ac.rs
Cells are sensitive to a variety of signals in their environment, which they respond to and
integrate. Signal transduction at the cellular level refers to the movement of signals from …
integrate. Signal transduction at the cellular level refers to the movement of signals from …
Oxidative stress and redox modulation potential in type 1 diabetes
MM Delmastro, JD Piganelli - Journal of Immunology Research, 2011 - Wiley Online Library
Redox reactions are imperative to preserving cellular metabolism yet must be strictly
regulated. Imbalances between reactive oxygen species (ROS) and antioxidants can initiate …
regulated. Imbalances between reactive oxygen species (ROS) and antioxidants can initiate …
Altered plasma profile of antioxidant proteins as an early correlate of pancreatic β cell dysfunction
Insulin resistance and β cell dysfunction contribute to the pathogenesis of type 2 diabetes.
Unlike insulin resistance, β cell dysfunction remains difficult to predict and monitor, because …
Unlike insulin resistance, β cell dysfunction remains difficult to predict and monitor, because …
Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes
J Montane, L Cadavez, A Novials - Diabetes, metabolic syndrome …, 2014 - Taylor & Francis
Type 2 diabetes (T2D) is a complex metabolic disorder characterized by hyperglycemia in
the context of insulin resistance, which precedes insulin deficiency as a result of β-cell …
the context of insulin resistance, which precedes insulin deficiency as a result of β-cell …
New insights for oxidative stress and diabetes mellitus
K Maiese - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …
NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells
Nucleotide-binding oligomerization domain protein-2 (NOD2) activation in skeletal muscle
cells has been associated with insulin resistance, but the underlying mechanisms are not yet …
cells has been associated with insulin resistance, but the underlying mechanisms are not yet …