Osteopontin (OPN) up-regulates pro-inflammatory cytokines from both T helper type 1 and T
helper type 17 cell pathways. We measured plasma OPN levels in Japanese multiple …

In the search for proteins that might play a role in the pathogenesis of multiple sclerosis
(MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene …

Inflammatory mediators are closely associated with the pathogenesis of neurodegenerative
changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Osteopontin …

Osteopontin (OPN) is an inflammatory cytokine highly expressed in multiple sclerosis (MS)
plaques. In a previous work, we showed that four OPN polymorphisms form three haplotypes …

Osteopontin (OPN) is a pro-inflammatory cytokine that can be secreted from many cells
including activated macrophages and T-lymphocytes. Elevated levels of osteopontin in the …

Osteopontin (OPN) is an extracellular matrix protein with chemokine, cytokine and integrin
properties. It has multiple immunological functions and is secreted by activated …

Biomarkers capable of predicting the clinical course and the rate of disease progression in
multiple sclerosis are currently unavailable. Our objective was to examine if the levels of …

Osteopontin (OPN) is highly expressed in demyelinating lesions in multiple sclerosis (MS)
and experimental autoimmune encephalomyelitis (EAE). OPN is cleaved by thrombin into N …

Inflammation is believed to play a role in Alzheimer's disease (AD). Osteopontin (OPN) is a
molecule involved in macrophage recruitment and activation and implicated in …

Osteopontin (OPN) exhibits pleiotropic functions and abundant transcripts for OPN are
present in brains of patients with multiple sclerosis (MS). The aim of this study was to …