[HTML][HTML] Cleavage of osteopontin by matrix metalloproteinase-12 modulates experimental autoimmune encephalomyelitis disease in C57BL/6 mice
A role for osteopontin (OPN) in promoting disease activity of multiple sclerosis or its animal
model experimental autoimmune encephalomyelitis (EAE) has recently been suggested. As …
model experimental autoimmune encephalomyelitis (EAE) has recently been suggested. As …
Plasma osteopontin is correlated with bone resorption markers in rheumatoid arthritis patients
H Iwadate, H Kobayashi, T Kanno… - International Journal …, 2014 - Wiley Online Library
Aim To assess whether any form of osteopontin (OPN) is correlated with bone resorption
markers or treatment effects in rheumatoid arthritis (RA). Method Subjects comprised 119 …
markers or treatment effects in rheumatoid arthritis (RA). Method Subjects comprised 119 …
[HTML][HTML] Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis
CC Hsiao, HJ Engelenburg, A Jongejan, J Zhu… - Iscience, 2023 - cell.com
The human brain is populated by perivascular T cells with a tissue-resident memory T (T
RM)-cell phenotype, which in multiple sclerosis (MS) associate with lesions. We investigated …
RM)-cell phenotype, which in multiple sclerosis (MS) associate with lesions. We investigated …
The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease
D Chabas, SE Baranzini, D Mitchell, CCA Bernard… - Science, 2001 - science.org
Multiple sclerosis is a demyelinating disease, characterized by inflammation in the brain and
spinal cord, possibly due to autoimmunity. Large-scale sequencing of cDNA libraries …
spinal cord, possibly due to autoimmunity. Large-scale sequencing of cDNA libraries …
[HTML][HTML] Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders
K Silva, C Hope-Lucas, T White, TK Hairston… - Journal of …, 2015 - Springer
The proinflammatory cytokine osteopontin (OPN) is elevated in the cerebrospinal fluid (CSF)
in individuals with HIV-associated neurocognitive disorders (HAND) and remains so in those …
in individuals with HIV-associated neurocognitive disorders (HAND) and remains so in those …
Osteopontin in the development of systemic sclerosis—relation to disease activity and organ manifestation
JM Lorenzen, R Krämer, M Meier, T Werfel… - …, 2010 - academic.oup.com
1 Department of Health. Copying letters to patients: good practice guidelines. London:
Department of Health, 2003. http://www. dh. gov. uk/dr_consum_dh/groups/dh_digital …
Department of Health, 2003. http://www. dh. gov. uk/dr_consum_dh/groups/dh_digital …
[HTML][HTML] Plasma levels of osteopontin identify patients at risk for organ damage in systemic lupus erythematosus
OJ Rullo, JMP Woo, MF Parsa, ADC Hoftman… - Arthritis research & …, 2013 - Springer
Introduction Osteopontin (OPN) has been implicated as a mediator of Th17 regulation via
type I interferon (IFN) receptor signaling and in macrophage activity at sites of tissue repair …
type I interferon (IFN) receptor signaling and in macrophage activity at sites of tissue repair …
Osteopontin in autoimmune disorders: current knowledge and future perspective
C Xu, Y Wu, N Liu - Inflammopharmacology, 2022 - Springer
Osteopontin (OPN) is a multifunctional cytokine and adhesion molecule, as well as an
unusual regulator for both innate and adaptive immune responses. Several immune cells …
unusual regulator for both innate and adaptive immune responses. Several immune cells …
Osteopontin: role in immune regulation and stress responses
KX Wang, DT Denhardt - Cytokine & growth factor reviews, 2008 - Elsevier
Recent research has led to a better but as yet incomplete understanding of the complex
roles osteopontin plays in mammalian physiology. A soluble protein found in all body fluids …
roles osteopontin plays in mammalian physiology. A soluble protein found in all body fluids …
[HTML][HTML] Osteopontin in systemic sclerosis and its role in dermal fibrosis
Osteopontin (OPN) is a matricellular protein with proinflammatory and profibrotic properties.
Previous reports demonstrate a role for OPN in wound healing and pulmonary fibrosis. Here …
Previous reports demonstrate a role for OPN in wound healing and pulmonary fibrosis. Here …