Objective The variety of disease phenotypes among patients with SLE challenges the
identification of new biomarkers reflecting disease activity and/or organ damage …

Central nervous system lymphoma (CNSL) is diagnostically challenging. The identification
of reliable and easy to measure biomarkers is desirable to facilitate diagnosis. Here, we …

Cerebrovascular disease (CeVD) and neurodegenerative dementia such as Alzheimer's
disease (AD) are frequently associated comorbidities in the elderly, sharing common risk …

Relapses and disease exacerbations are vexing features of multiple sclerosis. Osteopontin
(Opn), which is expressed in multiple sclerosis lesions, is increased in patients' plasma …

Osteopontin (OPN) is a multifunctional protein which has shown neuroprotective properties
in animal models of cerebral ischemia. Nevertheless, its role in acute human stroke has not …

Osteopontin (OPN), also called early T cell activation gene-1 (Eta-1) or secreted
phosphoprotein 1 (Spp1), has important functions in bone metabolism (1, 2) and in …

Background Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous
system that predominantly affects the optic nerves and spinal cord. Although NMO has long …

Background Osteopontin (OPN) is a proinflammatory biomarker, and neurofilament light
chain (NFL) levels reflect axonal damage. Resting-state functional MRI (rs-fMRI) defines …

Background Osteopontin (OPN) as a secreted signaling protein is dramatically induced in
response to cellular injury and neurodegeneration. Microglial inflammatory responses in the …

Despite effective and widely available suppressive anti-HIV therapy, the prevalence of mild
neurocognitive dysfunction continues to increase. HIV-associated neurocognitive disorder …