Osteopontin is associated with disease severity and antiphospholipid syndrome in well characterised Swedish cases of SLE
L Wirestam, M Frodlund, H Enocsson… - Lupus science & …, 2017 - lupus.bmj.com
Objective The variety of disease phenotypes among patients with SLE challenges the
identification of new biomarkers reflecting disease activity and/or organ damage …
identification of new biomarkers reflecting disease activity and/or organ damage …
Osteopontin in cerebrospinal fluid as diagnostic biomarker for central nervous system lymphoma
F Strehlow, S Bauer, P Martus, M Weller, P Roth… - Journal of neuro …, 2016 - Springer
Central nervous system lymphoma (CNSL) is diagnostically challenging. The identification
of reliable and easy to measure biomarkers is desirable to facilitate diagnosis. Here, we …
of reliable and easy to measure biomarkers is desirable to facilitate diagnosis. Here, we …
Plasma osteopontin as a biomarker of Alzheimer's disease and vascular cognitive impairment
Cerebrovascular disease (CeVD) and neurodegenerative dementia such as Alzheimer's
disease (AD) are frequently associated comorbidities in the elderly, sharing common risk …
disease (AD) are frequently associated comorbidities in the elderly, sharing common risk …
Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells
Relapses and disease exacerbations are vexing features of multiple sclerosis. Osteopontin
(Opn), which is expressed in multiple sclerosis lesions, is increased in patients' plasma …
(Opn), which is expressed in multiple sclerosis lesions, is increased in patients' plasma …
Osteopontin predicts long-term functional outcome among ischemic stroke patients
M Mendioroz, I Fernández-Cadenas, A Rosell… - Journal of …, 2011 - Springer
Osteopontin (OPN) is a multifunctional protein which has shown neuroprotective properties
in animal models of cerebral ischemia. Nevertheless, its role in acute human stroke has not …
in animal models of cerebral ischemia. Nevertheless, its role in acute human stroke has not …
Comment on" The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease"
T Blom, A Franzen, D Heinegård, R Holmdahl - Science, 2003 - science.org
Osteopontin (OPN), also called early T cell activation gene-1 (Eta-1) or secreted
phosphoprotein 1 (Spp1), has important functions in bone metabolism (1, 2) and in …
phosphoprotein 1 (Spp1), has important functions in bone metabolism (1, 2) and in …
[HTML][HTML] Increased cerebrospinal fluid osteopontin levels and its involvement in macrophage infiltration in neuromyelitis optica
Y Kariya, Y Kariya, T Saito, S Nishiyama, T Honda… - BBA clinical, 2015 - Elsevier
Background Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous
system that predominantly affects the optic nerves and spinal cord. Although NMO has long …
system that predominantly affects the optic nerves and spinal cord. Although NMO has long …
Microstructural and functional brain abnormalities in multiple sclerosis predicted by osteopontin and neurofilament light
Background Osteopontin (OPN) is a proinflammatory biomarker, and neurofilament light
chain (NFL) levels reflect axonal damage. Resting-state functional MRI (rs-fMRI) defines …
chain (NFL) levels reflect axonal damage. Resting-state functional MRI (rs-fMRI) defines …
Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection
FJ Mahmud, Y Du, E Greif, T Boucher… - Journal of …, 2020 - Springer
Background Osteopontin (OPN) as a secreted signaling protein is dramatically induced in
response to cellular injury and neurodegeneration. Microglial inflammatory responses in the …
response to cellular injury and neurodegeneration. Microglial inflammatory responses in the …
Osteopontin enhances HIV replication and is increased in the brain and cerebrospinal fluid of HIV-infected individuals
Despite effective and widely available suppressive anti-HIV therapy, the prevalence of mild
neurocognitive dysfunction continues to increase. HIV-associated neurocognitive disorder …
neurocognitive dysfunction continues to increase. HIV-associated neurocognitive disorder …