Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease

M Scatena, L Liaw, CM Giachelli - Arteriosclerosis, thrombosis, and …, 2007 - Am Heart Assoc
Osteopontin (OPN) is a multifunctional molecule highly expressed in chronic inflammatory
and autoimmune diseases, and it is specifically localized in and around inflammatory cells …

Quantification of osteopontin in human plasma with an ELISA: basal levels in pre-and postmenopausal women

DS Bautista, Z Saad, AF Chambers, KS Tonkin… - Clinical …, 1996 - Elsevier
Objectives: To develop an immunoassay for osteopontin (OPN), a secreted
phosphoglycoprotein that is implicated in a number of human diseases, and establish basal …

Both full-length and protease-cleaved products of osteopontin are elevated in infectious diseases

T Hattori, H Iwasaki-Hozumi, G Bai, H Chagan-Yasutan… - Biomedicines, 2021 - mdpi.com
Circulating full-length osteopontin (FL-OPN) is elevated in plasma from patients with various
infectious diseases, such as adult T-cell leukemia, Mycobacterium tuberculosis (TB) …

Association of osteopontin with osteoarthritis

C Cheng, S Gao, G Lei - Rheumatology international, 2014 - Springer
The joint disease osteoarthritis (OA) is the most common form of arthritis, which mainly
affects the older people. OA is becoming one of the major non-fatal health burdens of the …

Clinical significance of elevated osteopontin levels in head and neck cancer patients

M Eto, S Kodama, N Nomi, N Uemura, M Suzuki - Auris Nasus Larynx, 2007 - Elsevier
OBJECTIVES: Osteopontin (OPN) is associated with several human malignancies, but the
role of OPN in head and neck cancer (HNC) remains unclear. We investigated the …

Association of osteopontin with ischemic axonal death in periventricular leukomalacia

F Tanaka, Y Ozawa, Y Inage, K Deguchi, M Itoh… - Acta …, 2000 - Springer
Osteopontin (OPN) is a bone matrix protein expressed my macrophages and related to the
process of tissue calcification, and is also known to protect ischemic cells. To understand …

CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis

J Romme Christensen, L Börnsen… - Multiple Sclerosis …, 2013 - journals.sagepub.com
Background: The mechanism underlying disease progression in progressive multiple
sclerosis (MS) is uncertain. Pathological studies found widespread inflammation in …

OPN polymorphism is associated with the susceptibility to cervical spondylotic myelopathy and its outcome after anterior cervical corpectomy and fusion

J Wu, D Wu, K Guo, F Yuan, B Ran - Cellular Physiology and …, 2014 - karger.com
Background: Osteopontin (OPN) is reportedly involved in bone desorption, formation and
ectopic calcification. We sought to investigate the role of OPN gene polymorphism in the …

The value of osteopontin in the assessment of bone mineral density status in postmenopausal women

D Fodor, C Bondor, A Albu, S Simon… - Journal of …, 2013 - journals.sagepub.com
Background Osteopontin (OPN) has been implicated in bone remodeling by activating the
resorption process. We aimed to study the relationship between OPN, bone mineral density …

Elevated serum levels of osteopontin in HCV-associated lymphoproliferative disorders

M Libra, M Indelicato, V De Re, AL Zignego… - Cancer biology & …, 2005 - Taylor & Francis
Hepatitis C virus (HCV) infection is associated with chronic hepatitis, cirrhosis, and
hepatocellular carcinoma. Recent evidences have also suggested that HCV infection …