Alzheimer's disease (AD) is a complex multifactorial disorder with poorly characterized
pathogenesis. Our understanding of this disease would thus benefit from an approach that …

Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …

Integration of multi-omics data with molecular interaction networks enables elucidation of the
pathophysiology of Alzheimer's disease (AD). Using the latest genome-wide association …

Alzheimer's disease (AD) is a complex, multifactorial disease that has reached global
epidemic proportions. The challenge remains to fully identify its underlying molecular …

Gene mining has been a fruitful approach in the study of Alzheimer's disease (AD). As a new
starting point for studying AD, genetic and genomic investigations consistently strive to …

To generate new insights into the biology of Alzheimer's Disease (AD), we developed
methods to combine and reuse a wide variety of existing data sets in new ways. We first …

Dysregulation of gene expression in Alzheimer's disease (AD) remains elusive, especially at
the cell type level. Gene regulatory network, a key molecular mechanism linking …

Despite decades of genetic studies on late-onset Alzheimer's disease, the underlying
molecular mechanisms remain unclear. To better comprehend its complex etiology, we use …

Here, we report proteomic analyses of 129 human cortical tissues to define changes
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …

The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …