Suppression of endotoxin release and subsequent production of inflammatory cytokines is
crucial in the treatment of septic shock. We investigated the effect of clindamycin (CLI) on …

Ceftiofur is a new broad-spectrum, third-generation cephalosporin antibiotic for veterinary
use. Our laboratory has previously been reported that ceftiofur can modulate early cytokine …

Dexmedetomidine (Dex), a highly selective α2-adrenergic receptor agonist, has been shown
to attenuate systemic inflammatory response induced by lipopolysaccharide (LPS). The …

Macrolide antibacterials inhibit the production of various cytokines and the migration of
inflammatory cells. These anti-inflammatory actions of macrolides may be beneficial in …

Sepsis causes more than with 215,000 deaths per year in the United States alone. Death
can be caused by multiple system organ failure, with the lung, in the form of the acute …

Background: Sepsis is a serious, heterogeneous clinical entity produced by a severe and
systemic host inflammatory response to infection. Methotrexate (MTX) is a folate-antagonist …

Sepsis precipitates a systemic inflammatory stimulus that causes systemic release of
cytokines and sequestration of polymorphonuclear neutrophils, resulting in degranulation of …

Background Acute kidney injury occurred after sepsis, resulting in high mortality. This
research aims to elucidate the mechanistic effect of DEX on the renal inflammation …

Rationale: Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome with a
mortality of up to 40%. Precision medicine approaches targeting patients on the basis of …

Experimental pharmacotherapies for the acute respiratory distress syndrome (ARDS) have
not met with success in the clinical realm. We hypothesized that chemically modified …