Sepsis is a complex medical condition characterized by a systemic inflammatory response in
the setting of infection. We hypothesized that combining antibiotics plus an …

Neisseria meningitidis is responsible for septicemia and meningitis with high fatality that is
associated with an excessive inflammatory reaction particularly with hyperinvasive isolates …

Antibiotic-induced immunopathology associated with the release of bacterial cell wall
components has been suggested to contribute to poor outcomes in bacterial pneumonia …

Background Thalidomide is an inhibitor of tumour necrosis factor-alpha (TNFα) that has
been proven effective for the treatment of experimental sepsis by Escherichia coli. It was …

Antibiotics might, apart from an antimicrobial effect, also exert anti-inflammatory effects. The
novel antibiotic tigecycline, potentially useful in septic shock from gram-negative …

Results In Group 2, serum GSH-Px and SOD levels were statistically significantly higher than
in Group 1 (p< 0.05) and serum MDA levels were statistically significantly lower than in …

Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel
benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide …

Objective: This study aims to demonstrate the protective effect of doxycycline, an exogenous
inhibitor of matrix metalloproteinases-9 (MMP-9), in the acute lung injury induced by …

The mechanism of immunosuppression induced by severe sepsis is not fully understood.
The production of prostaglandin E 2 (PGE 2) during sepsis is well known, but its role in long …

Aim: Acute lung injury (ALI) is a life-threatening inflammatory syndrome that lacks an
effective therapy. Dioscin, a natural steroid saponin isolated from a variety of herbs, could …