Phospho‐specific plasma p‐tau181 assay detects clinical as well as asymptomatic Alzheimer's disease

S De Meyer, J Vanbrabant… - Annals of clinical …, 2022 - Wiley Online Library
Abstract Objective Plasma phosphorylated‐tau‐181 (p‐tau181) reliably detects clinical
Alzheimer's disease (AD) as well as asymptomatic amyloid‐β (Aβ) pathology, but is …

Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease neuropathology

PR Kac, F González-Ortiz, A Emeršič… - Nature …, 2024 - nature.com
Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations
with Alzheimer's disease (AD) neuropathologic change and clinical stage. Certain plasma p …

A novel ultrasensitive assay for plasma p‐tau217: performance in individuals with subjective cognitive decline and early Alzheimer's disease

F Gonzalez‐Ortiz, PCL Ferreira… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Detection of Alzheimer's disease (AD) pathophysiology among individuals
with mild cognitive changes and those experiencing subjective cognitive decline (SCD) …

Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease

S Janelidze, D Bali, NJ Ashton, NR Barthélemy… - Brain, 2023 - academic.oup.com
Plasma phospho-tau (p-tau) species have emerged as the most promising blood-based
biomarkers of Alzheimer's disease. Here, we performed a head-to-head comparison of p …

Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau-and amyloid-positron emission tomography

MM Mielke, CE Hagen, J Xu, X Chai, P Vemuri… - Alzheimer's & …, 2018 - Elsevier
Introduction We examined and compared plasma phospho-tau181 (pTau181) and total
tau:(1) across the Alzheimer's disease (AD) clinical spectrum;(2) in relation to brain amyloid …

[HTML][HTML] Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer's pathology

J Therriault, NJ Ashton, I Pola, G Triana-Baltzer… - …, 2024 - thelancet.com
Background Blood-based biomarkers of Alzheimer's disease (AD) have become
increasingly important as scalable tools for diagnosis and determining clinical trial eligibility …

Diagnostic accuracy of a plasma phosphorylated tau 217 immunoassay for Alzheimer disease pathology

NJ Ashton, WS Brum, G Di Molfetta, AL Benedet… - JAMA …, 2024 - jamanetwork.com
Importance Phosphorylated tau (p-tau) is a specific blood biomarker for Alzheimer disease
(AD) pathology, with p-tau217 considered to have the most utility. However, availability of p …

Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia

S Janelidze, N Mattsson, S Palmqvist, R Smith… - Nature medicine, 2020 - nature.com
Plasma phosphorylated tau181 (P-tau181) might be increased in Alzheimer's disease (AD),
but its usefulness for differential diagnosis and prognosis is unclear. We studied plasma P …

Equivalence of plasma p‐tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease

J Therriault, S Servaes, C Tissot… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Plasma biomarkers are promising tools for Alzheimer's disease (AD)
diagnosis, but comparisons with more established biomarkers are needed. METHODS We …

Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer's amyloid, tau and FDG PET status

XN Shen, YY Huang, SD Chen, Y Guo, L Tan… - Translational …, 2021 - nature.com
Abstract Plasma phosphorylated-tau181 (p-tau181) showed the potential for Alzheimer's
diagnosis and prognosis, but its role in detecting cerebral pathologies is unclear. We aimed …