A Klebsiella pneumoniae regulatory mutant has reduced capsule expression but retains hypermucoviscosity
KA Walker, TA Miner, M Palacios, D Trzilova… - MBio, 2019 - Am Soc Microbiol
The polysaccharide capsule is an essential virulence factor for Klebsiella pneumoniae in
both community-acquired hypervirulent strains as well as health care-associated classical …
both community-acquired hypervirulent strains as well as health care-associated classical …
The small protein RmpD drives hypermucoviscosity in Klebsiella pneumoniae
KA Walker, LP Treat, VE Sepúlveda, VL Miller - MBio, 2020 - Am Soc Microbiol
Klebsiella pneumoniae has a remarkable ability to cause a wide range of human diseases. It
is divided into two broad classes: classical strains that are a notable problem in health care …
is divided into two broad classes: classical strains that are a notable problem in health care …
Hypermucoviscosity regulator RmpD interacts with Wzc and controls capsular polysaccharide chain length
Klebsiella pneumoniae is a leading cause of nosocomial infections, including pneumonia,
bacteremia, and urinary tract infections. Treatment options are increasingly restricted by the …
bacteremia, and urinary tract infections. Treatment options are increasingly restricted by the …
Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains
M Palacios, TA Miner, DR Frederick, VE Sepulveda… - MBio, 2018 - Am Soc Microbiol
Klebsiella pneumoniae is widely recognized as a pathogen with a propensity for acquiring
antibiotic resistance. It is capable of causing a range of hospital-acquired infections (urinary …
antibiotic resistance. It is capable of causing a range of hospital-acquired infections (urinary …
The intersection of capsule gene expression, hypermucoviscosity and hypervirulence in Klebsiella pneumoniae
KA Walker, VL Miller - Current opinion in microbiology, 2020 - Elsevier
For∼ 30 years, two distinct groups of clinical isolates of Klebsiella pneumoniae have been
recognized. Classical strains (cKp) are typically isolated from patients with some degree of …
recognized. Classical strains (cKp) are typically isolated from patients with some degree of …
The Capsule Regulatory Network of Klebsiella pneumoniae Defined by density-TraDISort
Klebsiella pneumoniae infections affect infants and the immunocompromised, and the
recent emergence of hypervirulent and multidrug-resistant K. pneumoniae lineages is a …
recent emergence of hypervirulent and multidrug-resistant K. pneumoniae lineages is a …
Urine-mediated suppression of Klebsiella pneumoniae mucoidy is counteracted by spontaneous Wzc variants altering capsule chain length
S Khadka, BE Ring, RS Walker, LR Krzeminski… - Msphere, 2023 - Am Soc Microbiol
Klebsiella pneumoniae is a hospital-associated pathogen primarily causing urinary tract
infections (UTIs), pneumonia, and septicemia. Two challenging lineages include the …
infections (UTIs), pneumonia, and septicemia. Two challenging lineages include the …
The contribution of capsule polysaccharide genes to virulence of Klebsiella pneumoniae
KS Ko - Virulence, 2017 - Taylor & Francis
Klebsiella pneumoniae is a Gram-negative, non-motile bacterium that is found in the
environment, including in soil and surface water. K. pneumoniae readily colonizes human …
environment, including in soil and surface water. K. pneumoniae readily colonizes human …
A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness
LA Mike, AJ Stark, VS Forsyth, J Vornhagen… - PLoS …, 2021 - journals.plos.org
Hypervirulent K. pneumoniae (hvKp) is a distinct pathotype that causes invasive community-
acquired infections in healthy individuals. Hypermucoviscosity (hmv) is a major phenotype …
acquired infections in healthy individuals. Hypermucoviscosity (hmv) is a major phenotype …
RmpA2, an Activator of Capsule Biosynthesis in Klebsiella pneumoniae CG43, Regulates K2 cps Gene Expression at the Transcriptional Level
YC Lai, HL Peng, HY Chang - Journal of bacteriology, 2003 - Am Soc Microbiol
The rmpA2 gene, which encodes an activator for capsular polysaccharide (CPS) synthesis,
was isolated from a 200-kb virulence plasmid of Klebsiella pneumoniae CG43. Based on the …
was isolated from a 200-kb virulence plasmid of Klebsiella pneumoniae CG43. Based on the …