Vulnerability to chronic stress and the phenotypic heterogeneity of presbycusis with subjective tinnitus

J Ruan, X Hu, Y Liu, Z Han, Q Ruan - Frontiers in Neuroscience, 2022 - frontiersin.org
Age-related functional reserve decline and vulnerability of multiple physiological systems
and organs, as well as at the cellular and molecular levels, result in different frailty …

Progress on mechanisms of age-related hearing loss

W Yang, X Zhao, R Chai, J Fan - Frontiers in neuroscience, 2023 - frontiersin.org
Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly
people worldwide. It typically presents as progressive, irreversible, and usually affects the …

Cholinergic hypofunction in presbycusis-related tinnitus with cognitive function impairment: emerging hypotheses

Q Ruan, Z Yu, W Zhang, J Ruan, C Liu… - Frontiers in Aging …, 2018 - frontiersin.org
Presbycusis (age-related hearing loss) is a potential risk factor for tinnitus and cognitive
deterioration, which result in poor life quality. Presbycusis-related tinnitus with cognitive …

The neuroanatomical hallmarks of chronic tinnitus in comorbidity with pure-tone hearing loss

S Elmer, R Schmitt, N Giroud, M Meyer - Brain Structure and Function, 2023 - Springer
Tinnitus is one of the main hearing impairments often associated with pure-tone hearing
loss, and typically manifested in the perception of phantom sounds. Nevertheless, tinnitus …

Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network

YC Chen, X Li, L Liu, J Wang, CQ Lu, M Yang, Y Jiao… - elife, 2015 - elifesciences.org
Hearing loss often triggers an inescapable buzz (tinnitus) and causes everyday sounds to
become intolerably loud (hyperacusis), but exactly where and how this occurs in the brain is …

Corticostriatal functional connectivity of bothersome tinnitus in single-sided deafness

J Henderson-Sabes, Y Shang, PL Perez, JL Chang… - Scientific reports, 2019 - nature.com
Subjective tinnitus is an auditory phantom perceptual disorder without an objective
biomarker. Bothersome tinnitus in single-sided deafness (SSD) is particularly challenging to …

Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress

YC Chen, GD Chen, BD Auerbach, S Manohar… - Hearing research, 2017 - Elsevier
Tinnitus and hyperacusis are common and potentially serious hearing disorders associated
with noise-, age-or drug-induced hearing loss. Accumulating evidence suggests that tinnitus …

Cortico-limbic morphology separates tinnitus from tinnitus distress

AM Leaver, A Seydell-Greenwald… - Frontiers in systems …, 2012 - frontiersin.org
Tinnitus is a common auditory disorder characterized by a chronic ringing or buzzing “in the
ear.” Despite the auditory-perceptual nature of this disorder, a growing number of studies …

Early noise-induced hearing loss accelerates presbycusis altering aging processes in the cochlea

AR Fetoni, A Pisani, R Rolesi, F Paciello… - Frontiers in aging …, 2022 - frontiersin.org
Several studies identified hearing loss as a risk factor for aging-related processes, including
neurodegenerative diseases, as dementia and age-related hearing loss (ARHL). Although …

Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life

F Panza, M Lozupone, R Sardone… - … in Chronic Disease, 2019 - journals.sagepub.com
The peripheral hearing alterations and central auditory processing disorder (CAPD)
associated with age-related hearing loss (ARHL), may impact cognitive disorders in older …