The phenome represents the observable properties of an organism that have developed
under the continued influences of both genome and environmental factors. Phenotypic …

Mutant animals characterized by extended longevity provide valuable tools to study the
mechanisms of aging. Growth hormone and insulin-like growth factor-1 (IGF-1) constitute …

The complex, highly integrative endocrine system regulates all aspects of somatic
maintenance and reproduction and has been widely implicated as an important determinant …

Growth hormone receptor knockout (GHRKO) mice are remarkably long‐lived and have
improved glucose homeostasis along with altered energy metabolism which manifests …

There is increasing evidence that growth hormone (GH) and insulin-like growth factor 1 (IGF-
1) signaling (collectively referred to as somatotropic signaling) during development has a …

Reduced somatotropic [growth hormone (GH) and insulin-like growth factor-1 (IGF-1)] action
has been associated with delayed and slower aging, reduced risk of frailty, reduced age …

The discovery that in invertebrates, disruption of the insulin/insulin-like growth factor (IGF)-1
pathway extends life span and increases resistance to oxidative injury led to the hypothesis …

Key points Maternal obesity predisposes to metabolic dysfunction in male and female
offspring Maternal high‐fat diet consumption prior to and throughout pregnancy and …

There is conflicting information on the physiological role of growth hormone (GH) in the
control of aging. This study reports dual-energy x-ray absorptiometry (DXA) measurements …

Growth hormone receptor gene–disrupted (GHR−/−) mice are dwarf, insulin sensitive, and
long lived despite being obese. In order to identify characteristics associated with their …