Migraine and epilepsy are episodic disorders that share many clinical features and
underlying pathophysiological mechanisms. Cortical spreading depression (CSD), a wave …

Spreading depolarizations (SDs) are classically thought to be associated with spreading
depression of cortical activity. Here, we found that SDs in patients with subarachnoid …

Cortical spreading depression (CSD) may be the underlying mechanism of migraine aura.
The role of CSD in initiating a migraine headache remains to be determined, but it might …

Cortical spreading depression was described in 1943 by Aristides Leão, a Brazilian
neurophysiologist. Initially considered to be a mysterious event as it was discovered …

Few things are pathognomonic in medical practice, but the clinical history of the scintillating
scotoma marching slowly across the visual field is one of the closest to being a clinical home …

The initial phase in the development of a migraine is still poorly understood. Here, we
describe a previously unknown signaling pathway between stressed neurons and trigeminal …

Objective Cortical spreading depression (SD) is an intense depolarization underlying
migraine aura. Despite the weight of evidence linking SD to the pain phase of migraine …

Migraine headaches have a complex pathophysiology; both vascular and neuronal
mechanisms have been proposed. One possible scenario begins with brain-initiated events …

Fig. 1. Extracellular ionic concentrations, DC-potential, and single unit activity during
spreading depression in rat cortex. SD was elicited in frontal cortex, and recordings taken at …

Cortical spreading depolarization (CSD) is a spreading loss of ion homeostasis, altered
vascular response, change in synaptic architecture, and subsequent depression in electrical …