Previous findings from our laboratory demonstrated that some clonally expanded
cerebrospinal fluid (CSF) B cells from MS patients exhibit diminished mutation targeting …

Clonally expanded populations of Ig variable gene-mutated B cells are found in the central
nervous system (CNS) of subjects with multiple sclerosis (MS), suggesting the occurrence of …

Purpose: to determine whether cerebrospinal fluid (CSF) B cells exhibit clonal expansion in
patients recently diagnosed with multiple sclerosis (MS). CSF B cell clonal expansion was …

Clonally expanded populations of B cells carrying somatic mutations of Ig variable (V) region
genes have been detected in the CNS of subjects with multiple sclerosis (MS), suggesting …

B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique
accumulation of somatic hypermutation, within the B cell receptor, termed the antibody gene …

In the central nervous system of patients with multiple sclerosis, B cell aggregates populate
the meninges, raising the central question as to whether these structures relate to the B cell …

We re-engineered the immunoglobulin rearrangements from clonally expanded CSF B cells
of three Multiple Sclerosis patients as Fab fragments, and used three methods to test for their …

Single-cell RT-PCR was used to sample CD19+ B cell repertoires in cerebrospinal fluid
(CSF) of patients with multiple sclerosis (MS) or viral meningitis. Analysis of amplified Ab H …

Fluorescence-activated cell sorting (FACS) analysis of B cell subtypes in 17 CSF samples
from 15 patients with clinically-definite MS revealed that CD19+ B cells accounted for 2 to …

B cells are key contributors to chronic autoimmune pathology in multiple sclerosis (MS).
Clonally related B cells exist in the cerebrospinal fluid (CSF), meninges, and CNS …