Identification of Druggable Targets for Acinetobacter baumannii Via Subtractive Genomics and Plausible Inhibitors for MurA and MurB
N Kaur, M Khokhar, V Jain, PV Bharatam… - Applied biochemistry …, 2013 - Springer
Emergence of the multidrug-resistant pathogens has rendered the current therapies
ineffective thereby, resulting in the need for new drugs and drug targets. The accumulating …
ineffective thereby, resulting in the need for new drugs and drug targets. The accumulating …
Blocking the catalytic mechanism of MurC ligase enzyme from Acinetobacter baumannii: An in Silico guided study towards the discovery of natural antibiotics
Acinetobacter baumannii belongs to the most critical group of bacterial pathogens that are
resistant to large number of antibiotics, including the highly effective carbapenems and third …
resistant to large number of antibiotics, including the highly effective carbapenems and third …
Identification of novel non-homologous drug targets against Acinetobacter baumannii using subtractive genomics and comparative metabolic pathway analysis
Lack of effective antibiotics and the development of multidrug resistance in clinical isolates
of nosocomial pathogen Acinetobacter baumanni has necessitated the identification of novel …
of nosocomial pathogen Acinetobacter baumanni has necessitated the identification of novel …
Structure based drug designing and discovery of promising lead molecules against UDP-N-acetylenolpyruvoylglucosamine reductase (MurB): A potential drug target …
According to the world health organization (WHO) reports, Acinetobacter baumannii was
considered as one of the significant and first-line priority pathogens, which causes hospital …
considered as one of the significant and first-line priority pathogens, which causes hospital …
[HTML][HTML] Computer-Based Identification of Potential Druggable Targets in Multidrug-Resistant Acinetobacter baumannii: A Combined In Silico, In Vitro and In Vivo …
The remarkable rise in antimicrobial resistance is alarming for Acinetobacter baumannii,
which necessitates effective strategies for the discovery of promising anti-acinetobacter …
which necessitates effective strategies for the discovery of promising anti-acinetobacter …
Prioritization of Mur family drug targets against A. baumannii and identification of their homologous proteins through molecular phylogeny, primary sequence, and …
Abstract Background The World Health Organization (WHO) report stated that Acinetobacter
baumannii had been classified as one of the most important pathogenic bacteria causing …
baumannii had been classified as one of the most important pathogenic bacteria causing …
Identification of Ideal Multi-targeting Bioactive Compounds Against Mur Ligases of Enterobacter aerogenes and Its Binding Mechanism in Comparison with Chemical …
V Chakkyarath, J Natarajan - Interdisciplinary Sciences: Computational …, 2019 - Springer
Enterobacter aerogenes have been reported as important opportunistic and multi-resistant
bacterial pathogens for humans during the last three decades in hospital wards. The …
bacterial pathogens for humans during the last three decades in hospital wards. The …
[PDF][PDF] In silico identification of novel drug targets in acinetobacter baumannii by subtractive genomic approach
Objective: Multiple drug resistance (MDR) in bacteria, particularly Gram-negative bacilli, has
significantly hindered the treatment of infections caused by these bacteria. This results in the …
significantly hindered the treatment of infections caused by these bacteria. This results in the …
Discovery of multi-target mur enzymes inhibitors with anti-mycobacterial activity through a Scaffold approach
M Kumari, M Waseem, N Subbarao - Journal of Biomolecular …, 2023 - Taylor & Francis
In the present study, we generated a ligand-based scaffold model from a known bioactive
datasets of mur enzymes of other species to identify multi-targeting inhibitors as …
datasets of mur enzymes of other species to identify multi-targeting inhibitors as …
Comparative subtractive proteomics based ranking for antibiotic targets against the dirtiest superbug: Acinetobacter baumannii
Multidrug-resistant Acinetobacter baumannii is indeed to be the most successful nosocomial
pathogen responsible for myriad infections in modern health care system. Computational …
pathogen responsible for myriad infections in modern health care system. Computational …
相关搜索
- acinetobacter baumannii subtractive genomics
- drug targets subtractive genomics
- acinetobacter baumannii drug target
- plausible inhibitors subtractive genomics
- acinetobacter baumannii plausible inhibitors
- druggable targets plausible inhibitors
- pathway analysis subtractive genomics
- lead molecules drug target
- acinetobacter baumannii silico identification
- pathway analysis drug targets
- acinetobacter baumannii lead molecules
- acinetobacter baumannii pathway analysis
- chemical inhibitors mur ligases
- acinetobacter baumannii mure ligase
- acinetobacter baumannii natural antibiotics
- acinetobacter baumannii catalytic mechanism