Lack of intermediate‐affinity interleukin‐2 receptor in mice leads to dependence on interleukin‐2 receptor α, β and γ chain expression for T cell growth
P Chastagner, JL Moreau, Y Jacques… - European journal of …, 1996 - Wiley Online Library
Abstract An interleukin (IL)‐4 dependant mouse T cell clone 8.2 derived from an IL‐2‐
dependent T cell line was characterized. As measured by flow cytometric analysis and …
dependent T cell line was characterized. As measured by flow cytometric analysis and …
In Situ Expression of Interleukin-4 (IL-4) Receptors in Human Brain Tumors and Cytotoxicity of a Recombinant IL-4 Cytotoxin in Primary Glioblastoma …
BH Joshi, P Leland, A Asher, RA Prayson, F Varricchio… - Cancer Research, 2001 - AACR
We have reported that human malignant glioma cell lines express high levels of plasma
membrane interleukin-4 receptors (IL-4R). We have also reported that biopsy/surgical …
membrane interleukin-4 receptors (IL-4R). We have also reported that biopsy/surgical …
Activation by IL-2, but not IL-4, up-regulates the expression of the p55 subunit of the IL-2 receptor on IL-2-and IL-4-dependent T cell lines.
DL Jankovic, M Gibert, D Baran, J Ohara… - … (Baltimore, Md.: 1950 …, 1989 - journals.aai.org
We have investigated the effects of IL-2 and IL-4 on different parameters of T cell activation
using three T cell lines. The Th cell line L14 and the cytotoxic T cell line C30. 1, both grown …
using three T cell lines. The Th cell line L14 and the cytotoxic T cell line C30. 1, both grown …
Identification of interleukin 4 receptor‐associated proteins and expression of both high‐and low‐affinity binding on human lymphoid cells
BMJ Foxwell, G Woerly, B Ryffel - European journal of …, 1989 - Wiley Online Library
Abstract Interleukin 4 (IL 4) produced by activated T cells expresses its biological effects on
T and B lymphocytes by binding to specific membrane receptors. Cross‐linking of human …
T and B lymphocytes by binding to specific membrane receptors. Cross‐linking of human …
High-affinity and intermediate-affinity forms of the human interleukin 2 receptor, expressed in an interleukin 9-dependent murine T cell line, deliver proliferative signals …
C Pitton, A Rebollo, J Van Snick, J Thèze, A Garcia - Cytokine, 1993 - Elsevier
Although several reports have claimed that the p70 IL-2R per se transduces a growth signal
in lymphoid and non-lymphoid systems, there is no convincing evidence for this in lymphoid …
in lymphoid and non-lymphoid systems, there is no convincing evidence for this in lymphoid …
Induction of cell surface interleukin 2 receptor alpha chain expression on non-T lymphoid leukemia cells
K Nakase, K Kita, S Shirakawa, I Tanaka, M Tsudo - Leukemia research, 1994 - Elsevier
We examined nine cases of adult non-T lymphoid leukemia to investigate the cell surface
inducibility of interleukin 2 receptor α chain (IL-2Rα) and β chain (IL-2Rβ) after in vitro …
inducibility of interleukin 2 receptor α chain (IL-2Rα) and β chain (IL-2Rβ) after in vitro …
Multiple γc‐receptor expression in adult T‐cell leukemia
H Baba, Y Yamada, N Mori… - European journal of …, 2002 - Wiley Online Library
Constitutive expression of the IL‐2 receptor (IL‐2R) on adult T‐cell leukemia (ATL) cells and
the presence of permanent IL‐2‐dependent ATL cell lines indicate that the signal …
the presence of permanent IL‐2‐dependent ATL cell lines indicate that the signal …
Interleukin‐2 receptor β‐chain (p70–75) expressed on leukemic cells from adult T cell leukemia patients
T Kodaka, T Uchiyama, T Ishikawa… - Japanese journal of …, 1990 - Wiley Online Library
To determine whether the interleukin‐2 receptor (IL‐2R) β‐chain (p70–75) is expressed on
lenkemic cells from patients with adult T cell leukemia (ATL) as well as α‐chain (p55, Tac) …
lenkemic cells from patients with adult T cell leukemia (ATL) as well as α‐chain (p55, Tac) …
Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement …
H Otani, JP Siegel, M Erdos… - Proceedings of the …, 1992 - National Acad Sciences
We have established IL-3-dependent 32D myeloid progenitor cells stably expressing the
human IL-2 receptor beta chain (IL-2R beta). Whereas parental 32D cells proliferated only in …
human IL-2 receptor beta chain (IL-2R beta). Whereas parental 32D cells proliferated only in …
Expression of high-affinity IL-4 receptors on murine tumour infiltrating lymphocytes and their up-regulation by IL-2.
RK Puri, DS Finbloom, P Leland, H Mostowski… - …, 1990 - ncbi.nlm.nih.gov
Abstract Since interleukin-2 (IL-2) and IL-4 act in concert to support the development of
cytotoxic T lymphocytes (CTL) and the generation of antigen-specific tumour infiltrating …
cytotoxic T lymphocytes (CTL) and the generation of antigen-specific tumour infiltrating …