In the present study, we have investigated the leukemic cells obtained from 16 patients with
acute myeloid leukemia (AML) at diagnosis for the membrane expression of p55 (alpha) and …

Background Previous studies have suggested that some of the limitations associated with
the administration of high-dose exogenous interleukin 2 (IL2) may be overcome, at least …

We have recently reported that a variety of solid human tumor cells express high-affinity
interleukin-4 receptors (IL-4R). In this study, we have compared structural characteristics of …

The nature of the interleukin 2 (IL-2) receptor on purified human B lymphocytes was
examined. Both normal and malignant cells showed evidence of a 70–75,000 mol. wt (p75) …

We previously established a monoclonal antibody, TU11 mAb, which is specific for human IL-
2 receptor (IL-2R) beta chain (p75) and does not inhibit IL-2-binding to IL-2R beta. Using …

Reconstitution with mouse interleukin‐2 (IL‐2) receptor subunits demonstrated that the
mouse IL‐2 receptor complex was different from the human complex in the α chain …

Human carcinomas spontaneously express abundant IL-2R beta but little IL-2R alpha on the
cell surface, contain mRNA for IL-2R beta-and IL-2R alpha-chains, and may be inhibited in …

To determine the effects of a cytokine on cognate receptor expression in normal and
neoplastic cells, the interleukin-3 receptor (IL-3R) complex was examined in the parental IL …

Human T-cell leukemia virus (HTLV)-infected cell lines derived from adult T-cell leukemia
(ATL) express constitutively the receptor for Interleukin-2 (IL-2-R) and the associated antigen …

In order to study the possible role of the T-lymphocyte growth factor, Interleukin 2 (IL-2),
and/or of the IL-2 receptor in the autonomous growth of leukaemic cells, 15 mouse …