Abstract Interleukin 2 (IL 2) delivers cell growth signal by virtue of its interaction with the high‐
affinity receptor complex, which consists of two distinct IL 2‐binding molecules: the IL 2 …

Recent studies have demonstrated efficacy of immunotherapies including interleukin-2 (IL-2)
in the treatment of malignancies in rodents and humans. High levels of IL-2 receptor-positive …

Cell surface expression of the high affinity IL-2R regulates, in part, the proliferative response
occurring in Ag-or mitogen-activated T cells. The functional high affinity IL-2R is composed …

In a previous study, we reported that adult T-cell leukemia (ATL) cells produce interleukin 1
(IL1)-like factors that stimulate murine thymocyte proliferation, the production of interleukin 2 …

Abstract Murine interleukin 5 (IL-5), a lymphokine produced by helper T cells, is involved in
the regulation of growth and differentiation of B cells and other hematopoletic cells. The …

The regulation of interleukin 1 (IL 1) receptor expression on a human large granular
lymphocyte cell line, YT, and fate of internalized 125I-labeled IL 1 beta (125I-IL 1 beta) were …

Abstract Human interleukin 2 (IL-2) receptor cDNA derived from HUT 102B2 cells was stably
expressed in murine L cells. These L cell transfectants (a) displayed surface receptors of the …

Human leukemias are illnesses of hemopoietic stem cells that go through processes of self-
replication and partial differentiation under the control of as yet largely unknown growth and …

Abstract Interleukin (IL-2) and IL-2Rβ/γ have been shown to be expressed in human
carcinomas in culture and in situ. Recently, expression of endogenous IL-2 and IL-2R in the …

A mouse hybridoma cell line, TU27, producing an mAb was established. TU27 mAb reacted
with various human and Gibbon ape T cell lines bearing the IL-2R p75 (IL-2Rp75), but not …