Although the role of interleukin 2 (IL 2) in mature T lymphocyte function is well documented,
its effect on hematopoietic progenitor cells is less well characterized. Here we have used …

Interleukin 2 (IL-2)-mediated signaling through its high-affinity receptor involves a complex
interrelationship between IL-2 and two IL-2-binding chains, IL-2R alpha and beta chains …

Previous studies have shown that binding of interleukin 1 (IL-1) to its receptor and
intracellular processing of the IL-1/IL-1 receptor complex appear to be different in B-and T …

cDNA clones corresponding to an Mr approximately 80,000 receptor (type I receptor) for
interleukin‐1 (IL‐1) have been isolated previously by mammalian expression. Here, we …

We have previously described a unique molecular species of Interleukin 1 spontaneously
produced by a human EBV-transformed B-cell line. This IL 1 shares a number of biological …

Mouse monoclonal antibodies were produced against MT-2 cell line derived from adult T-
cell leukemia or human T-cell leukemia virus-rich fraction therefrom. Two IgG1 antibodies …

The proliferative response of fresh peripheral blood leukemic cells from eight adult T cell
leukemia (ATL) patients to interleukin-4 (IL-4) was studied to determine the possibility that …

The binding of interleukin-2 (IL-2) to the IL-2 receptor (IL-2R) on human T-cells is a key
regulatory event which is absolutely required for T-cell-mediated immune responses. To …

Abstract Recently, interleukin-4 (IL-4) has been clarified as having T-cell growth factor
activity; therefore, it becomes of interest whether IL-4, as well as interleukin-2 (IL-2), affects …

In this report we show that IL‐3 up‐regulates the expression of IL‐6‐receptors on a plasma
cell leukaemia cell line which proliferates in response to both IL‐3 and IL‐6. Quantitative …