Computational design, synthesis, and assessment of 3-(4-(4-(1, 3, 4-oxadiazol-2-yl)-1 H-imidazol-2-yl) phenyl)-1, 2, 4-oxadiazole derivatives as effective epidermal …
NR Khedkar, M Sindkhedkar, A Joseph - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
The epidermal growth factor receptor (EGFR) enzyme plays a critical role in governing the
cell cycle, positioning it as a promising target for the development of anticancer drugs. In this …
cell cycle, positioning it as a promising target for the development of anticancer drugs. In this …
In vitro and in silico evaluation of anticancer activity of new indole-based 1, 3, 4-oxadiazoles as EGFR and COX-2 inhibitors
Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial
targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1 H-indol-3-yl) …
targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1 H-indol-3-yl) …
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors
AM Srour, NS Ahmed, SS Abd El-Karim… - Bioorganic & Medicinal …, 2020 - Elsevier
Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
Rational design-aided discovery of novel 1, 2, 4-oxadiazole derivatives as potential EGFR inhibitors
A molecular dynamics-based sampling of epidermal growth factor receptor tyrosine kinase
(EGFR-TK) was carried out to search for energetically more stable protein, which was then …
(EGFR-TK) was carried out to search for energetically more stable protein, which was then …
Computational Design, Synthesis, and Bioevaluation of 2-(Pyrimidin-4-yl) oxazole-4-carboxamide Derivatives: Dual Inhibition of EGFRWT and EGFRT790M with …
NR Khedkar, M Sindkhedkar, A Joseph - Bioorganic Chemistry, 2024 - Elsevier
The ongoing research in cancer treatment underscores the significance of dual epidermal
growth factor receptor (EGFR) kinase inhibitors targeting both mutant and wild-type variants …
growth factor receptor (EGFR) kinase inhibitors targeting both mutant and wild-type variants …
Naproxen based 1, 3, 4-oxadiazole derivatives as EGFR inhibitors: Design, synthesis, anticancer, and computational studies
MM Alam, S Nazreen, ASA Almalki, AA Elhenawy… - Pharmaceuticals, 2021 - mdpi.com
A library of novel naproxen based 1, 3, 4-oxadiazole derivatives (8–16 and 19–26) has been
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
Novel 2-(5-Aryl-4, 5-dihydropyrazol-1-yl) thiazol-4-one as EGFR inhibitors: synthesis, biological assessment and molecular docking insights
Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …
Identification of 1, 2, 4-oxadiazoles-based novel EGFR inhibitors: Molecular dynamics simulation-guided identification and in vitro ADME studies
V Unadkat, S Rohit, P Parikh, K Patel… - OncoTargets and …, 2022 - Taylor & Francis
Background In this work, we have identified heterocyclic derivatives with 1, 2, 4 oxadiazole
scaffold mimicking the functions of tyrosine kinase inhibitors. Fourteen molecules that …
scaffold mimicking the functions of tyrosine kinase inhibitors. Fourteen molecules that …
Molecular Modeling of some 1, 3, 4-Oxadiazole Derivatives as EGFR Inhibitors for the Treatment of Cancer
SM Patil, SV Bhandari, VA Patil… - Letters in Drug …, 2024 - benthamdirect.com
Background: Cancer is a group of illnesses characterised by the impartial increase and
unfolding of somatic cells. A variety of natural compounds, such as curcumin, zingiberine …
unfolding of somatic cells. A variety of natural compounds, such as curcumin, zingiberine …
Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress
Epidermal growth factor receptor (EGFR) is a vital intermediate in cell signaling pathway
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …