The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the
present study, we demonstrate that heteromerization of adenosine A 1 receptors (A 1 Rs) …

Since 1990 it has been known that dimers are the basic functional form of nearly all G-
protein-coupled receptors (GPCRs) and that homo-and heterodimerization may play a key …

[Frontiers in Bioscience 13, 2391-2399, January 1, 2008] 2391 Adenosine A1-A2A receptor
heteromers: new targets for caffeine in Page 1 [Frontiers in Bioscience 13, 2391-2399, January …

A2A adenosine receptors (A2ARs) are expressed with the greatest abundance in the
striatum and other nuclei of the basal ganglia. The segregated expression of A2ARs on the …

Adenosine is a neuromodulator that controls neurotransmitter release through inhibitory A1
and facilitatory A2A receptors. Although both adenosine receptor-mediated inhibition and …

The effect of oral treatment with caffeine, in doses that are known to produce marked
adaptive effects, was investigated on A1 and A2A receptors in the mouse brain. Caffeine …

Recently evidence has been presented that adenosine A2A and dopamine D2 receptors
form functional heteromeric receptor complexes as demonstrated in human neuroblastoma …

Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …

Adenosine A2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …

Background It has been hypothesized that heteromers of adenosine A 2A receptors (A2AR)
and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic nerve terminals mediate …