Background It has been hypothesized that heteromers of adenosine A 2A receptors (A2AR)
and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic nerve terminals mediate …

Previous work has been carried out on the effects of adenosine on transmitter release and
on the excitability of postsynaptic neurones, but little is known about the effects of adenosine …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …

By analyzing the functional role of adenosine receptor heteromers, we review a series of
new concepts that should modify our classical views of neurotransmission in the central …

Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …

Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …

The physiological meaning of the coexpression of adenosine A2A receptors and group I
metabotropic glutamate receptors in γ-aminobutyric acid (GABA) ergic striatal neurons is …

Recently, evidence has emerged that seven transmembrane G protein-coupled receptors
may be present as homo-and heteromers in the plasma membrane. Here we describe a new …

The results presented in this paper show that adenosine A2A receptor (A2AR) form
homodimers and that homodimers but not monomers are the functional species at the cell …