Endogenous adenosine in nervous tissue, a central link between energy metabolism and
neuronal activity, varies according to behavioral state and (patho) physiological conditions; it …

The A1 adenosine receptor is the best characterized of the widely distributed purinergic
receptor family. The purified brain A1 receptor is a monomeric 35‐to 36‐kDa glycoprotein …

The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …

Adenosine's effects result from a balanced activation of inhibitory A1 and facilitatory A2A
receptors. Because in aged animals there is an increased number of A2A receptors, we now …

The nucleus accumbens is considered to be critically involved in the control of complex
motivated behaviors. By modulating its glutamatergic excitatory input, mesolimbic …

Evaluation of adenosine A2 receptor function in the mammalian CNS has been impeded by
the lack ofhighly selective A2 receptor agonists. The present investigations describe the …

Dopamine D2 receptors (Rs) and adenosine A2ARs are coexpressed on striatopallidal
neurons, where they mediate opposing actions. In agreement with the idea that D2Rs …

The A 2a adenosine receptor, a member of the G protein-coupled receptor family, is
important in the regulation of dopaminergic pathways of the brain and in platelet and …

The adenosine A2A receptor (A2AR) has long been implicated in cardiovascular disorders.
As more selective A2AR ligands are being identified, its roles in other disorders, such as …

The effects of putative A3 adenosine receptor antagonists of three diverse chemical classes
(the flavonoid MRS 1067, the 6-phenyl-1, 4-dihydropyridines MRS 1097 and MRS 1191 …