The relative contribution of yolk sac (YS)–derived cells to the circulating definitive
hematopoietic progenitor cell (HPC) pool that seeds the fetal liver remains controversial due …

Hematopoietic cell clusters in the aorta of vertebrate embryos play a pivotal role in the
formation of the adult blood system. Despite their importance, hematopoietic clusters have …

We report that embryonic stem cells efficiently undergo differentiation in vitro to mesoderm
and hematopoietic cells and that this in vitro system recapitulates days 6.5 to 7.5 of mouse …

The developmental origin of hematopoietic stem cells has been for decades the subject of
great interest. Once thought to emerge from the yolk sac, hematopoietic stem cells have now …

The yolk sac is the sole niche and source of cells for primitive erythropoiesis from E1 to E5 of
chicken development. It is also the main niche and source of cells for early definitive …

The majority of B lymphocytes in the adult mouse are generated in the bone marrow from
hematopoietic stem cells (HSCs) that first appear in the aorta-gonado-mesonephros region …

The yolk sac is the first observed site of hematopoiesis during mouse ontogeny. Primitive
erythroid cells are the most well-recognized cell lineages produced from this tissue. In …

During development of the mouse embryo, blood cells are generated from mesodermal
precursors at specific times and locations. Using various in vivo and in vitro systems, we are …

OBJECTIVE: To review the process of blood-cell formation in the murine and human yolk
sac. DATA SOURCES: Most articles were selected from the PubMed database. DATA …

Adult-repopulating hematopoietic stem cells (HSCs) emerge in low numbers in the
midgestation mouse embryo from a subset of arterial endothelium, through an endothelial-to …