Interictal spikes and epileptic seizures: their relationship and underlying rhythmicity

PJ Karoly, DR Freestone, R Boston, DB Grayden… - Brain, 2016 - academic.oup.com
We report on a quantitative analysis of electrocorticography data from a study that acquired
continuous ambulatory recordings in humans over extended periods of time. The objectives …

Relationships between interictal spiking and seizures: human and experimental evidence

J Gotman - Canadian journal of neurological sciences, 1991 - cambridge.org
Epileptic seizures of focal origin often occur unpredictably as do interictal spikes. It is often
assumed that spikes increase prior to seizures of focal origin and that antiepileptic …

Do interictal spikes drive epileptogenesis?

K Staley, JL Hellier, FE Dudek - The Neuroscientist, 2005 - journals.sagepub.com
Interictal spikes are periodic, very brief bursts of neuronal activity that are observed in the
electroencephalogram of patients with chronic epilepsy. These spikes are useful …

Interictal spiking increases after seizures but does not after decrease in medication

J Gotman, DJ Koffler - Electroencephalography and clinical …, 1989 - Elsevier
In patients with focal epilepsy, EEG spike rate fluctuates considerably over time. We had
previously shown that seizure occurrence played an important role in these fluctuations. We …

Clinical relevance of quantified intracranial interictal spike activity in presurgical evaluation of epilepsy

A Hufnagel, M Dümpelmann, J Zentner, O Schijns… - …, 2000 - Wiley Online Library
Purpose: Electrocorticograms of 32 patients with medically intractable seizures, recorded
through intracranial electrodes, were retrospectively analyzed. The objective was to assess …

Interictal spikes on intracranial recording: behavior, physiology, and implications

SS Spencer, II Goncharova, RB Duckrow… - …, 2008 - Wiley Online Library
Purpose: The physiological, pathological, and clinical meaning of interictal spikes (IISs)
remains controversial. We systematically analyzed the frequency, occurrence, and …

Interictal spikes: harbingers or causes of epilepsy?

KJ Staley, A White, FE Dudek - Neuroscience letters, 2011 - Elsevier
Interictal spikes are brief paroxysmal electrographic discharges observed between
spontaneous recurrent seizures in epileptic patients. The relationship between interictal …

Does interictal spiking change prior to seizures?

A Katz, DA Marks, G McCarthy, SS Spencer - … and clinical neurophysiology, 1991 - Elsevier
We studied 10 patients with intractable epilepsy being evaluated for epilepsy surgery for
preictal changes in spiking. All patients were implanted with intracranial electrodes and …

Spatial distribution of interictal spikes fluctuates over time and localizes seizure onset

EC Conrad, SB Tomlinson, JN Wong, KF Oechsel… - Brain, 2020 - academic.oup.com
The location of interictal spikes is used to aid surgical planning in patients with medically
refractory epilepsy; however, their spatial and temporal dynamics are poorly understood. In …

Do interictal spikes sustain seizures and epileptogenesis?

M Avoli, G Biagini, M De Curtis - Epilepsy currents, 2006 - journals.sagepub.com
Interictal spiking is seen in the EEG of epileptic patients between seizures. To date, the roles
played by interictal events in seizure occurrence and in epileptogenesis remain elusive …