CD38, a surface glycoprotein of unrestricted lineage, is an ectoenzyme (adenosine
diphosphate [ADP] ribosyl cyclase/cyclic ADP-ribose hydrolase) that regulates cytoplasmic …

Receptors used by natural killer (NK) cells to mediate natural cytotoxicity are poorly defined,
although it is now clear that a number of adhesion molecules can serve this function. CD38 …

Human CD38 is a signal transduction molecule, and, concurrently, an ectoenzyme
catalyzing the synthesis and degradation of cyclic ADP-ribose (cADPR), a potent Ca2+ …

Natural killer (NK) cell activation is the result of a balance between positive and negative
signals triggered by specific membrane receptors. We report here the activation of NK cells …

CD38 is an ectoenzyme that utilizes NAD+ and is expressed by many cells of hematopoietic
origin. Antibodies to CD38 potentiate many biological activities on lymphocytes, including …

The CD27 molecule is expressed on a portion of natural killer (NK) cells as well as T and B
cells. To provide the functional capacity of CD27 molecule on NK cells, we here highly …

CD38 is an∼ 45-kDa type II transmembrane glycoprotein expressed by hematopoietic and
nonhematopoietic cells. Its surface expression is under complex control and varies during …

CD38 is a type II transmembrane glycoprotein that is extensively expressed on cells of
bematopoietic and non‐hematopoietic lineage. Although the intracellular domain of CD38 is …

Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors
involved in the catabolism of extracellular nucleotides. CD38-receptor activities are …

Throughout life, cells of all hematopoietic lineages are continuously generated from a
common set of multipotent stem cells that have the potential for both self-renewal and …