Macroautophagy/autophagy is a dynamic process, and newly synthesized autophagosomes
need to fuse with lysosomes to complete the full process, which is referred to as autophagic …

Background Chronic ethanol (EtOH) consumption decelerates the catabolism of long‐lived
proteins, indicating that it slows hepatic macroautophagy (hereafter called autophagy) a …

Background & Aims Defects in lysosome function and autophagy contribute to the
pathogenesis of alcoholic liver disease. We investigated the mechanisms by which alcohol …

Autophagy is an important lysosome-mediated intracellular degradation pathway required
for tissue homeostasis. Dysregulation of liver autophagy is closely associated with different …

Acute and chronic ethanol administration increase autophagic vacuole (ie, autophagosome;
AV) content in liver cells. This enhancement depends on ethanol oxidation. Here, we used …

Alcoholic beverages are one of the most popular drinks in the world, but ethanol can induce
significant liver pathology. We have found that ethanol treatment results in autophagy …

Autophagy is an intracellular pathway by which lysosomes degrade and recycle long-lived
proteins and cellular organelles. The effects of ethanol on autophagy are complex but recent …

The pathogenic mechanism underlying alcoholic fatty liver (AFL) is not clear. Autophagy is a
self-digestion process that is critical for the maintenance of cellular homeostasis and …

Ethanol increases hepatic mitophagy driven by unknown mechanisms. Type 1 mitophagy
sequesters polarized mitochondria for nutrient recovery and cytoplasmic remodeling. In …

Ethanol is a neuroteratogen and neurodegeneration is the most devastating consequence of
developmental exposure to ethanol. The mechanisms underlying ethanol-induced …