The hallmark of tumours is the ability of cancerous cells to promote vascular growth, to
disseminate and invade to distant organs. The metastatic process is heavily influenced by …

Glioblastoma (GBM) angiogenesis is critical for tumor growth and recurrence, making it a
compelling therapeutic target. Here, a disease-relevant, vascularized tumoroid in vitro model …

The tumor microenvironment is a key factor in the progression and metastasis of cancer, the
complexity of which is not reproducible using two-dimensional (2D) culture models. While …

Introduction There is a growing appreciation for including a complex, vascularised stroma in
three-dimensional (3D) tumour models to recapitulate the native tumour microenvironment …

In vitro three-dimensional (3D) tumour models mimic natural cancer tissue in vivo, bridging
the gap between conventional 2D in vitro testing and animal models. Stromal and cancer …

Cell–microenvironment interactions play a critical role in the transformation of normal cells
into cancer; however, the underlying mechanisms and effects are far from being well …

The tumor microenvironment (TME) plays a significant role in cancer progression and thus
modeling it will advance our understanding of cancer growth dynamics and response to …

Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …

Tractable human tissue-engineered 3D models of cancer that enable fine control of tumor
growth, metabolism, and reciprocal interactions between different cell types in the tumor …

The development of blood vessels, referred to as angiogenesis, is an intricate process
regulated spatially and temporally through a delicate balance between the qualitative and …