Mechanistic insight into gel formation of co-amorphous resveratrol and piperine during dissolution process

J Han, C Zhang, Y Zhang, X Liu, J Wang - International Journal of …, 2023 - Elsevier
Different from previous co-amorphous systems, co-amorphous resveratrol and piperine
(namely RES-PIP CM) showed much lower dissolution in comparison to the original two …

Self-gelation involved in the transformation of resveratrol and piperine from a co-amorphous system into a co-crystal system

J Han, L Li, Q Yu, D Zheng, Y Song, J Zhang, Y Gao… - …, 2022 - pubs.rsc.org
Co-amorphous and co-crystal systems are attractive crystal-engineering strategies for poorly
soluble drugs. Intermolecular interactions between components play a key role in the …

[HTML][HTML] Mechanistic insight into gel-induced aggregation of amorphous curcumin during dissolution process

J Han, L Li, Z Pang, M Su, X He, S Qian, J Zhang… - European Journal of …, 2022 - Elsevier
Amorphous curcumin (CUR) exhibited a decreased dissolution rate in comparison with the
crystalline counterpart due to its gel formation during dissolution. The main purpose of the …

A novel drug–drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide

M Su, Y Xia, Y Shen, W Heng, Y Wei, L Zhang, Y Gao… - RSC …, 2020 - pubs.rsc.org
Tadalafil and repaglinide, categorized as BCS class II drugs, have low oral bioavailabilities
due to their poorly aqueous solubilities and dissolutions. The aim of this study was to …

Study on co-amorphous emerging solubilization behavior after gelation during dissolution: The importance of complexation and anti-crystallization

F Pu, S Wang, J Yang, J Yang, Y Hong, Y Guo… - International Journal of …, 2024 - Elsevier
Co-amorphous (CM) is a promising technology for enhancing the aqueous solubility of
insoluble drugs, but the gelation phenomenon has often occurred during the dissolution …

Co-amorphous systems using epigallocatechin-3-gallate as a co-former: Stability, in vitro dissolution, in vivo bioavailability and underlying molecular mechanisms

J Chen, H Li, X Li, D Yuan, H Cheng, Y Ke… - European Journal of …, 2022 - Elsevier
Co-amorphous strategy has been extensively investigated to improve the dissolution of
hydrophobic drugs. Here, epigallocatechin-3-gallate (EGCG) was exploited as a co-former …

The solid dispersion of resveratrol with enhanced dissolution and good system physical stability

C Yu, C Zhang, X Guan, D Yuan - Journal of Drug Delivery Science and …, 2023 - Elsevier
Resveratrol is a non-flavonoid polyphenol with multiple biological activities; however, the
specific properties of resveratrol present limitations for its clinical application. This study …

Crystallization of amorphous solid dispersions of resveratrol during preparation and storage—Impact of different polymers

LA Wegiel, LJ Mauer, KJ Edgar, LS Taylor - Journal of pharmaceutical …, 2013 - Elsevier
The objective of this study was to investigate intermolecular interactions between resveratrol
and polymers in amorphous blends and to study the potential correlations between …

[HTML][HTML] Dissolution changes in drug-amino acid/biotin co-amorphous systems: decreased/increased dissolution during storage without recrystallization

Z Zou, Q Huang, X Li, X Liu, L Yin, Y Zhao… - European Journal of …, 2023 - Elsevier
Co-amorphous systems have been proven to be a promising strategy to address the poor
water solubility of poorly water-soluble drugs. Generally, the initial dissolution behaviors …

Deaggregation and crystallization inhibition by small amount of polymer addition for a co-amorphous curcumin-magnolol system

J Han, L Li, M Su, W Heng, Y Wei, Y Gao, S Qian - Pharmaceutics, 2021 - mdpi.com
Different from previously reported co-amorphous systems, a co-amorphous curcumin-
magnolol (CUR-MAG CM) system, as compared with its crystalline counterparts, exhibited …