Mechanistic insight into gel formation of co-amorphous resveratrol and piperine during dissolution process
J Han, C Zhang, Y Zhang, X Liu, J Wang - International Journal of …, 2023 - Elsevier
Different from previous co-amorphous systems, co-amorphous resveratrol and piperine
(namely RES-PIP CM) showed much lower dissolution in comparison to the original two …
(namely RES-PIP CM) showed much lower dissolution in comparison to the original two …
Self-gelation involved in the transformation of resveratrol and piperine from a co-amorphous system into a co-crystal system
J Han, L Li, Q Yu, D Zheng, Y Song, J Zhang, Y Gao… - …, 2022 - pubs.rsc.org
Co-amorphous and co-crystal systems are attractive crystal-engineering strategies for poorly
soluble drugs. Intermolecular interactions between components play a key role in the …
soluble drugs. Intermolecular interactions between components play a key role in the …
[HTML][HTML] Mechanistic insight into gel-induced aggregation of amorphous curcumin during dissolution process
J Han, L Li, Z Pang, M Su, X He, S Qian, J Zhang… - European Journal of …, 2022 - Elsevier
Amorphous curcumin (CUR) exhibited a decreased dissolution rate in comparison with the
crystalline counterpart due to its gel formation during dissolution. The main purpose of the …
crystalline counterpart due to its gel formation during dissolution. The main purpose of the …
A novel drug–drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide
M Su, Y Xia, Y Shen, W Heng, Y Wei, L Zhang, Y Gao… - RSC …, 2020 - pubs.rsc.org
Tadalafil and repaglinide, categorized as BCS class II drugs, have low oral bioavailabilities
due to their poorly aqueous solubilities and dissolutions. The aim of this study was to …
due to their poorly aqueous solubilities and dissolutions. The aim of this study was to …
Study on co-amorphous emerging solubilization behavior after gelation during dissolution: The importance of complexation and anti-crystallization
F Pu, S Wang, J Yang, J Yang, Y Hong, Y Guo… - International Journal of …, 2024 - Elsevier
Co-amorphous (CM) is a promising technology for enhancing the aqueous solubility of
insoluble drugs, but the gelation phenomenon has often occurred during the dissolution …
insoluble drugs, but the gelation phenomenon has often occurred during the dissolution …
Co-amorphous systems using epigallocatechin-3-gallate as a co-former: Stability, in vitro dissolution, in vivo bioavailability and underlying molecular mechanisms
J Chen, H Li, X Li, D Yuan, H Cheng, Y Ke… - European Journal of …, 2022 - Elsevier
Co-amorphous strategy has been extensively investigated to improve the dissolution of
hydrophobic drugs. Here, epigallocatechin-3-gallate (EGCG) was exploited as a co-former …
hydrophobic drugs. Here, epigallocatechin-3-gallate (EGCG) was exploited as a co-former …
The solid dispersion of resveratrol with enhanced dissolution and good system physical stability
C Yu, C Zhang, X Guan, D Yuan - Journal of Drug Delivery Science and …, 2023 - Elsevier
Resveratrol is a non-flavonoid polyphenol with multiple biological activities; however, the
specific properties of resveratrol present limitations for its clinical application. This study …
specific properties of resveratrol present limitations for its clinical application. This study …
Crystallization of amorphous solid dispersions of resveratrol during preparation and storage—Impact of different polymers
The objective of this study was to investigate intermolecular interactions between resveratrol
and polymers in amorphous blends and to study the potential correlations between …
and polymers in amorphous blends and to study the potential correlations between …
[HTML][HTML] Dissolution changes in drug-amino acid/biotin co-amorphous systems: decreased/increased dissolution during storage without recrystallization
Z Zou, Q Huang, X Li, X Liu, L Yin, Y Zhao… - European Journal of …, 2023 - Elsevier
Co-amorphous systems have been proven to be a promising strategy to address the poor
water solubility of poorly water-soluble drugs. Generally, the initial dissolution behaviors …
water solubility of poorly water-soluble drugs. Generally, the initial dissolution behaviors …
Deaggregation and crystallization inhibition by small amount of polymer addition for a co-amorphous curcumin-magnolol system
J Han, L Li, M Su, W Heng, Y Wei, Y Gao, S Qian - Pharmaceutics, 2021 - mdpi.com
Different from previously reported co-amorphous systems, a co-amorphous curcumin-
magnolol (CUR-MAG CM) system, as compared with its crystalline counterparts, exhibited …
magnolol (CUR-MAG CM) system, as compared with its crystalline counterparts, exhibited …