Background Gene expression is epigenetically regulated by a combination of histone
modifications and methylation of CpG dinucleotides in promoters. In normal cells, CpG-rich …

Background One of the hallmarks of cancer is the disruption of gene expression patterns.
Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA …

Background Abnormal epigenetic marking is well documented in gene promoters of cancer
cells, but the study of distal regulatory siteshas lagged behind. We performed a systematic …

Extensive changes in DNA methylation are common in cancer and may contribute to
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …

Epigenetic gene regulation is a key determinant of heritable gene expression patterns and is
critical for normal cellular function. Dysregulation of epigenetic transcriptional control is a …

Background Cytosine DNA methylation is widely described as a transcriptional repressive
mark with the capacity to silence promoters. Epigenome engineering techniques enable …

Tissue specific patterns of methylated cytosine residues vary with age, can be altered by
environmental factors, and are often abnormal in human disease yet the cellular …

Background DNA methylation is an important type of epigenetic modification involved in
gene regulation. Although strong DNA methylation at promoters is widely recognized to be …

DNA methylation is an important epigenetic marker associated with gene expression
regulation in eukaryotes. While promoter methylation is relatively well characterized, the role …

As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …