Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes
Background Gene expression is epigenetically regulated by a combination of histone
modifications and methylation of CpG dinucleotides in promoters. In normal cells, CpG-rich …
modifications and methylation of CpG dinucleotides in promoters. In normal cells, CpG-rich …
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer
Background One of the hallmarks of cancer is the disruption of gene expression patterns.
Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA …
Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA …
DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes
Background Abnormal epigenetic marking is well documented in gene promoters of cancer
cells, but the study of distal regulatory siteshas lagged behind. We performed a systematic …
cells, but the study of distal regulatory siteshas lagged behind. We performed a systematic …
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
Extensive changes in DNA methylation are common in cancer and may contribute to
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …
Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells
Epigenetic gene regulation is a key determinant of heritable gene expression patterns and is
critical for normal cellular function. Dysregulation of epigenetic transcriptional control is a …
critical for normal cellular function. Dysregulation of epigenetic transcriptional control is a …
Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability
Background Cytosine DNA methylation is widely described as a transcriptional repressive
mark with the capacity to silence promoters. Epigenome engineering techniques enable …
mark with the capacity to silence promoters. Epigenome engineering techniques enable …
DNA methylation of the first exon is tightly linked to transcriptional silencing
F Brenet, M Moh, P Funk, E Feierstein, AJ Viale… - PloS one, 2011 - journals.plos.org
Tissue specific patterns of methylated cytosine residues vary with age, can be altered by
environmental factors, and are often abnormal in human disease yet the cellular …
environmental factors, and are often abnormal in human disease yet the cellular …
Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation
Background DNA methylation is an important type of epigenetic modification involved in
gene regulation. Although strong DNA methylation at promoters is widely recognized to be …
gene regulation. Although strong DNA methylation at promoters is widely recognized to be …
A diverse epigenetic landscape at human exons with implication for expression
DNA methylation is an important epigenetic marker associated with gene expression
regulation in eukaryotes. While promoter methylation is relatively well characterized, the role …
regulation in eukaryotes. While promoter methylation is relatively well characterized, the role …
Dynamic DNA methylation across diverse human cell lines and tissues
As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …
a complex relationship with gene expression, plays an important role in defining cell types …
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