We developed a pharmacophore model for type II inhibitors that was used to guide the
construction of a library of kinase inhibitors. Kinome-wide selectivity profiling of the library …

Small molecule inhibitors of signaling pathways have proven to be extremely useful for the
development of therapeutic strategies for human cancers. Blocking the tumor-promoting …

TGFβ family ligands, which include the TGFβs, BMPs, and activins, signal by forming a
ternary complex with type I and type II receptors. For TGFβs and BMPs, structures of ternary …

BMP7 and activin are members of the transforming growth factor β superfamily. Here we
characterize endogenous activin and BMP7 signaling pathways in P19 embryonic …

Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1) plays an
important role in vascular development, remodeling, and pathologic angiogenesis. Here we …

Germ line mutations in one of two distinct genes, endoglin or ALK-1, cause hereditary
hemorrhagic telangiectasia (HHT), an autosomal dominant disorder of localized …

Bone morphogenetic proteins (BMPs) are secreted cytokines that control the fate and
function of many different cell types. They exert their cellular responses via heteromeric …

The transforming growth factor-ß (TGF-β) signaling pathway plays a pivotal role in diverse
cellular processes. TGF-β switches its role from a tumor suppressor in normal or dysplastic …

Transforming growth factor (TGF)-β is a secreted multifunctional cytokine that signals via
plasma membrane TGF-β type I and type II receptors and intercellular SMAD transcriptional …

Activin, myostatin and other members of the TGF-β superfamily signal through a combination
of type II and type I receptors, both of which are transmembrane serine/threonine kinases …