Hypoxia–inducible factor (HIF) remains the central focus of oxygen sensing during hypoxia.
HIF is a heterodimeric transcription factor consisting of an oxygen-regulated alpha-and a …

Hypoxia-inducible factor-1α (HIF-1α) 1 is a global transcriptional regulator of the hypoxic
response. Under normoxic conditions, HIF-1α is recognized by the von Hippel-Lindau tumor …

Hypoxia-inducible factor (HIF) is central in coordinating many of the transcriptional
adaptations to hypoxia. Composed of a heterodimer of® and subunits, the® subunit is …

Hypoxia-inducible factors (HIFs) are heterodimeric oxygen-sensitive basic helix-loop-helix
transcription factors that play central roles in cellular adaptation to low oxygen environments …

In normoxic cells the hypoxia‐inducible factor‐1α (HIF‐1α) is rapidly degraded by the
ubiquitin‐proteasome pathway, and activation of HIF‐1α to a functional form requires protein …

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls
angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes …

Hypoxia‐inducible factor (HIF), a transcriptional complex conserved from Caenorhabditis
elegans to vertebrates, plays a pivotal role in cellular adaptation to low oxygen availability …

The hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that mediates adaptive
cellular responses to decreased oxygen availability (hypoxia). At normoxia, HIF-1α is …

Abstract Hypoxia-inducible factor-1α (HIF-1α) induction and associated transcription were
investigated during high cell density, focusing on the negative regulator of HIF-1α …

Many functions have been assigned to the von Hippel‐Lindau tumor suppressor gene
product (pVHL), including targeting the alpha subunits of the heterodimeric transcription …