Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor
(EGFR) gene in lung cancers have generated enormous interest, because they predict for …

Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor
receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these …

Recent discovery of mutations in the tyrosine kinase domain of the epidermal growth factor
receptor (EGFR) gene in lung adenocarcinoma greatly stimulated biomarker research on …

Lung cancers that harbor somatic activating mutations in the gene for the epidermal growth
factor receptor (EGFR) depend on mutant EGFR for their proliferation and survival; therefore …

Introduction: Epidermal growth factor receptor (EGFR) signaling pathway plays a crucial role
in the development and progression of lung cancer. We searched for mutations of EGFR …

BACKGROUND: Individualized treatment is an attractive challenge that may allow for more
effective and safer treatment of human disease. Activating mutations in the epidermal growth …

Background After the discovery of somatic mutations in the tyrosine kinase domain (exons
18–24) of the epidermal growth factor receptor (EGFR) correlating with responses of non …

The discovery of mutations in the tyrosine kinase domain of the epidermal growth factor
receptor (EGFR) gene in non-small cell lung cancer (NSCLC) accelerated the research of …

The epidermal growth factor receptor (EGFR) gene product is a receptor tyrosine kinase (TK)
that affects many important downstream pathways. The recent finding that mutations in …

Purpose: Activating somatic mutations in the epidermal growth factor receptor (EGFR) gene
are present in a small subset of lung adenocarcinomas. These mutations cluster in specific …