β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the
increasing emergence of resistance to them, developed by bacteria producing β-lactamase …

Importance of the field: β-Lactam antibiotics are among the most frequently prescribed
antibiotics used to treat bacterial infections. However, their utility is being threatened by the …

Antimicrobial resistance constitutes one of the major threats regarding pathogenic
microorganisms. Gramnegative pathogens, such as Enterobacteriaceae (specially those …

β-Lactams are the most widely used class of antibiotics. Since the discovery of
benzylpenicillin in the 1920s, thousands of new penicillin derivatives and related β-lactam …

Since the 1940s β-lactam antibiotics have been used to treat bacterial infections. However,
emergence and dissemination of β-lactam resistance has reached the point where many …

Highlights•It's crucial to identify the PK–PD efficacy determinant for a β-lactamase
inhibitor.•It's crucial to identify β-lactamase inhibitor exposures that prevent …

β-lactamase-mediated resistance to β-lactam antibiotics is an increasing threat to clinical
antimicrobial chemotherapy. The combinations of β-lactam antibiotics and β-lactamase …

Since the introduction of penicillin, β-lactam antibiotics have been the antimicrobial agents
of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantly threatened …

As the incidence of Gram-negative bacterial infections for which few effective treatments
remain increases, so does the contribution of drug-hydrolyzing β-lactamase enzymes to this …

Antibiotic resistance, and the emergence of pan-resistant clinical isolates, seriously
threatens our capability to treat bacterial diseases, including potentially deadly hospital …