Statins are widely used in the treatment of dyslipidemia and associated cardiovascular
abnormalities including atherosclerosis, hypertension and coronary heart disease. Needless …

Significance: Endothelial dysfunction and the imbalance between nitric oxide (NO) and
reactive oxygen species production in the vascular endothelium are important early steps in …

Statin-based drugs are the mainstay of therapy for coronary artery disease. Recent insights
into the cellular mechanisms of this class of drugs suggest that modulation of nitric oxide …

Endothelial dysfunction is now recognised as an important process in the pathogenesis of
atherosclerosis. Nitric oxide (NO) release by the endothelium regulates blood flow …

In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects
including improvements in heart failure (HF), reduced blood pressure, prevention of the …

Lipid-lowering treatment with statins is one of the most effective therapeutic strategies in
cardiovascular medicine because they reduce cardiovascular risk in both primary and …

Certain pleiotropic activities reported for 3-hydroxy-3-methylglutaryl coenzyme A (HMG-
CoA) reductase inhibitors (statins) are related to reductions in cellular cholesterol …

Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, referred to as
“statins” have been extensively reported to possess lipid lowering effects by inhibiting the …

Hypercholesterolemia is a major risk factor in the development of cardiovascular disease
and HMG-CoA reductase inhibitors (ie statins) were originally designed to reduce serum …

Background—Treatment with statins improves clinical outcome, but the exact mechanisms of
pleiotropic statin effects on vascular function in human atherosclerosis remain unclear. We …