Physiological cardiac growth is a feature of normal postnatal development in which an
increase in cardiac muscle cell diameter is observed as infants mature to adults. 1 This …

The Akt signaling pathway controls several cellular functions in the cardiovascular system;
however, its role in atherogenesis is unknown. Here, we show that the genetic ablation of …

Akt, a serine-threonine kinase, regulates multiple cellular processes in vascular cells. We
have previously documented that Akt activates integrins and Akt1 deficiency results in matrix …

The serine/threonine kinase AKT functions as a critical mediator of signaling downstream of
PI3 kinase. Studies over the last two decades have firmly established the importance of AKT …

Constitutive activation of serine/threonine kinase Akt causes uncontrolled cell-cycle
progression in different cell types and in malignancy. To investigate how Akt activation …

The serine/threonine protein kinase Akt (protein kinase B) phosphorylates endothelial cell
nitric oxide synthase (eNOS) and enhances its ability to generate nitric oxide (NO). Because …

The Akt family of serine-threonine kinases participates in diverse cellular processes,
including the promotion of cell survival, glucose metabolism, and cellular protein synthesis …

Protein kinase Bα (PKBα/Akt-1) is a key mediator of multiple signaling pathways involved in
angiogenesis, cell proliferation and apoptosis among others. The unphosphorylated form of …

The serine/threonine kinase Akt functions intracellularly as a cardinal nodal point for a
constellation of converging upstream signaling pathways, which involve stimulation of …

Endothelial nitric oxide synthase (eNOS) is an important modulator of angiogenesis and
vascular tone [1]. It is stimulated by treatment of endothelial cells in a phosphatidylinositol 3 …