Angiogenesis—the develoment of microvasculature—requires, in part, directed endothelial
cell motility and responsiveness to external signals. Several of the proteins, which modulate …

The serine/threonine protein kinase Akt is involved in a variety of cellular processes
including cell proliferation, survival, metabolism and gene expression. It is essential in …

Akt/PKB is a serine/threonine protein kinase that functions as a critical regulator of cell
survival and proliferation. Akt/PKB family comprises three highly homologous members …

Akt/PKB is a serine/threonine kinase, which controls vital cellular functions such as cell
survival/apoptosis, cell cycle progression and glucose metabolism. Akt/PKB acts down …

The serine/threonine protein kinase B (PKB, also known as Akt) constitutes an important
node in diverse signaling cascades downstream of growth factor receptor tyrosine kinases …

The signalling pathways operational in quiescent, post-development vasculature remain
enigmatic. Here we show that unlike neovascularization, endothelial Akt signalling in …

Integrin-linked kinase (ILK) is a phosphoinositide 3-kinase-dependent serine/threonine
kinase that interacts with β integrins. Here we show that endothelial cell (EC)-specific …

Kinases of the Akt family are integral and essential components in growth factor signaling
pathways activated downstream of the membrane bound phospho-inositol-3 kinase. In light …

AKT activation requires phosphorylation of the activation loop (T308) by 3-phosphoinositide-
dependent protein kinase 1 (PDK1) and the hydrophobic motif (S473) by the mammalian …

The PI 3-K signaling pathway has been the subject of intense investigation for over a
decade because it regulates a multitude of cellular processes. Deregulation of this pathway …